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dc.contributor.authorWei, W
dc.contributor.authorBastiaansen-Jenniskens, YM
dc.contributor.authorSuijkerbuijk, M
dc.contributor.authorKops, N
dc.contributor.authorBos, PK
dc.contributor.authorVerhaar, JAN
dc.contributor.authorZuurmond, A-M
dc.contributor.authorDell'Accio, F
dc.contributor.authorvan Osch, GJVM
dc.date.accessioned2017-11-06T11:00:07Z
dc.date.available2017-11-06T11:00:07Z
dc.date.issued2017-04-18
dc.date.submitted2017-11-04T14:13:23.722Z
dc.identifier.citationWei, W., Bastiaansen-Jenniskens, Y. M., Suijkerbuijk, M., Kops, N., Bos, P. K., Verhaar, J. A.N., Zuurmond, A.-M., Dell'Accio, F. and van Osch, G. J.V.M. (2017), High fat diet accelerates cartilage repair in DBA/1 mice. J. Orthop. Res., 35: 1258–1264. doi:10.1002/jor.23280en_US
dc.identifier.issn0736-0266
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/28630
dc.description.abstractObesity is a well-known risk factor for osteoarthritis, but it is unknown what it does on cartilage repair. Here we investigated whether a high fat diet (HFD) influences cartilage repair in a mouse model of cartilage repair. We fed DBA/1 mice control or HFD (60% energy from fat). After 2 weeks, a full thickness cartilage defect was made in the trochlear groove. Mice were sacrificed, 1, 8, and 24 weeks after operation. Cartilage repair was evaluated on histology. Serum glucose, insulin and amyloid A were measured 24 h before operation and at endpoints. Immunohistochemical staining was performed on synovium and adipose tissue to evaluate macrophage infiltration and phenotype. One week after operation, mice on HFD had defect filling with fibroblast-like cells and more cartilage repair as indicated by a lower Pineda score. After 8 weeks, mice on a HFD still had a lower Pineda score. After 24 weeks, no mice had complete cartilage repair and we did not detect a significant difference in cartilage repair between diets. Bodyweight was increased by HFD, whereas serum glucose, amyloid A and insulin were not influenced. Macrophage infiltration and phenotype in adipose tissue and synovium were not influenced by HFD. In contrast to common wisdom, HFD accelerated intrinsic cartilage repair in DBA/1 mice on the short term. Resistance to HFD induced inflammatory and metabolic changes could be associated with accelerated cartilage repair. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1258–1264, 2017.en_US
dc.description.sponsorshipThe Anna Fonds, Dutch Arthritis Association, Dutch Technology Foundation STWen_US
dc.format.extent1258 - 1264
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJOURNAL OF ORTHOPAEDIC RESEARCH
dc.rights"This is the peer reviewed version of the following article: Wei, W., Bastiaansen-Jenniskens, Y. M., Suijkerbuijk, M., Kops, N., Bos, P. K., Verhaar, J. A.N., Zuurmond, A.-M., Dell'Accio, F. and van Osch, G. J.V.M. (2017), High fat diet accelerates cartilage repair in DBA/1 mice. J. Orthop. Res., 35: 1258–1264. doi:10.1002/jor.23280, which has been published in final form at https://doi.org/10.1002/jor.23280. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
dc.subjectobesityen_US
dc.subjectcartilage repairen_US
dc.subjectanimal modelen_US
dc.subjectinflammationen_US
dc.subjecthigh fat dieten_US
dc.titleHigh Fat Diet Accelerates Cartilage Repair in DBA/1 Miceen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jor.23280
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403089500014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a
pubs.issue6
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute/Experimental Medicine & Rheumatology
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/William Harvey Research Institute/REF William Harvey Research Institute
pubs.publication-statusPublished
pubs.volume35


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