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dc.contributor.authorRasijeff, AMP
dc.contributor.authorWithers, M
dc.contributor.authorBurke, JM
dc.contributor.authorJackson, W
dc.contributor.authorScott, SM
dc.date.accessioned2017-07-17T09:36:28Z
dc.date.issued2017-06-22
dc.date.issued2017-06-22
dc.date.submitted2017-07-11T20:16:15.007Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/24885
dc.description.abstractBACKGROUND: Anorectal manometry is the most commonly performed investigation for assessment of anorectal dysfunction. Findings from previous studies comparing water-perfused (WP) and solid-state (SS) techniques in the anorectum are conflicting. We compared anal sphincter pressure at rest and during dynamic maneuvers (squeezing and coughing) in healthy volunteers using SS and WP high-resolution anorectal manometry (HR-ARM) employing equivalent catheter configurations, a standardized protocol, and identical data acquisition and analysis software. METHODS: Sixty healthy volunteers (40F; median age: 40; range: 18-74) underwent WP and SS HR-ARM in randomized order. Anal resting pressure, and squeeze and cough increments were measured. Median pressure and 5th and 95th percentiles were calculated for each maneuver and compared using Wilcoxon signed-rank test. Bland and Altman plots were used to assess agreement between the systems. The impact of gender and parity was also explored. KEY RESULTS: Anal sphincter pressure measurements during squeeze (P<.001) and cough (P<.001) were significantly higher using SS HR-ARM than WP HR-ARM. No differences were seen at rest between the two types of catheter (nulliparous: P=.304; parous: P=.390; males: P=.167). Normal ranges for SS and WP manometry from this small group of healthy volunteers are presented. CONCLUSIONS & INFERENCES: Greater sensitivity to rapid pressure change is one of the advantages associated with SS HR-ARM. This is reflected in the differences observed during dynamic maneuvers performed during this study. Catheter type should be taken into consideration when selecting normal ranges for comparison to disease states.
dc.description.sponsorshipFunding for the water-perfused catheters and volunteer payments was provided by Ardmore Healthcare Ltd and Medical Measurement Systems.en_US
dc.languageeng
dc.language.isoenen_US
dc.relation.ispartofNeurogastroenterol Motil
dc.rights"This is the peer reviewed version of the following article: Rasijeff AMP, Withers M, Burke JM, Jackson W, Scott SM. High-resolution anorectal manometry: A comparison of solid-state and water-perfused catheters. Neurogastroenterol Motil. 2017;e13124. https://doi.org/10.1111/nmo.13124, which has been published in final form at https://doi.org/10.1111/nmo.13124. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
dc.subjectHealthy volunteers
dc.subjectManometry
dc.subjectNormative data
dc.subjectSolid-state
dc.subjectWater-perfused
dc.titleHigh-resolution anorectal manometry: A comparison of solid-state and water-perfused catheters.
dc.typeJournal Article
dc.identifier.doi10.1111/nmo.13124
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28639425
pubs.organisational-group/Queen Mary University of London
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Blizard Institute
pubs.organisational-group/Queen Mary University of London/Faculty of Medicine & Dentistry/Blizard Institute/Neuroscience and Trauma
pubs.publication-statusPublished online


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