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Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin.

dc.contributor.authorKodji, Xen_US
dc.contributor.authorAubdool, AAen_US
dc.contributor.authorBrain, SDen_US
dc.date.accessioned2017-05-12T14:22:10Z
dc.date.available2016-09-17en_US
dc.date.issued2016-10en_US
dc.date.submitted2017-05-04T00:21:11.502Z
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/23059
dc.description.abstractThis review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.en_US
dc.description.sponsorshipX.K. is funded by the British Pharmacological Society’s A.J. Clark Studentship and A.A.A. is funded by the British Heart Foundation.en_US
dc.format.extent195 - 201en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofCurr Res Transl Meden_US
dc.rights(c) 2016 Elsevier Masson SAS.
dc.subjectNeuropeptidesen_US
dc.subjectPeripheral vasculatureen_US
dc.subjectSensory nervesen_US
dc.subjectSkin inflammationen_US
dc.subjectTransient receptor potential channelsen_US
dc.subjectAnimalsen_US
dc.subjectCell Communicationen_US
dc.subjectDermatitisen_US
dc.subjectHumansen_US
dc.subjectIrritantsen_US
dc.subjectKeratinocytesen_US
dc.subjectMicrocirculationen_US
dc.subjectNerve Tissue Proteinsen_US
dc.subjectNeuralgiaen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectNeuropeptidesen_US
dc.subjectNociceptionen_US
dc.subjectNociceptorsen_US
dc.subjectPhysical Stimulationen_US
dc.subjectPruritusen_US
dc.subjectSensory Receptor Cellsen_US
dc.subjectSkinen_US
dc.subjectTransient Receptor Potential Channelsen_US
dc.subjectVasodilationen_US
dc.titleEvidence for physiological and pathological roles for sensory nerves in the microvasculature and skin.en_US
dc.typeArticle
dc.identifier.doi10.1016/j.retram.2016.09.002en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27939458en_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume64en_US
dcterms.dateAccepted2016-09-17en_US


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