Evidence for physiological and pathological roles for sensory nerves in the microvasculature and skin.
Volume
64
Pagination
195 - 201
DOI
10.1016/j.retram.2016.09.002
Journal
Curr Res Transl Med
Issue
Metadata
Show full item recordAbstract
This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.