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Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene.
Rowe, HM; Lopes, L; Ikeda, Y; Bailey, R; Barde, I; Zenke, M; Chain, BM; Collins, MK (2006-02)Lentiviral vectors encoding antigens are promising vaccine candidates because they transduce dendritic cells (DC) in vivo and prime CTL responses. Here we examine their stimulation of antigen-specific CD4(+) T cells, ... -
T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
Okoye, I; Wang, L; Pallmer, K; Richter, K; Ichimura, T; Haas, R; Crouse, J; Choi, O; Heathcote, D; Lovo, E (2015-04-16)Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion ... -
Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.
Chiurchiù, V; Leuti, A; Dalli, J; Jacobsson, A; Battistini, L; Maccarrone, M; Serhan, CN (2016-08-24)Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins. The immunomodulatory role of SPMs ...