| dc.contributor.author | Williams, MJ | en_US |
| dc.contributor.author | Werner, B | en_US |
| dc.contributor.author | Graham, TA | en_US |
| dc.contributor.author | Sottoriva, A | en_US |
| dc.date.accessioned | 2016-10-18T11:10:06Z | |
| dc.date.available | 2016-03-02 | en_US |
| dc.date.issued | 2016-07 | en_US |
| dc.date.submitted | 2016-09-29T11:06:03.567Z | |
| dc.identifier.issn | 2372-3556 | en_US |
| dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/15910 | |
| dc.description.abstract | Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution. | en_US |
| dc.format.extent | e1162897 - ? | en_US |
| dc.language | eng | en_US |
| dc.relation.ispartof | Mol Cell Oncol | en_US |
| dc.rights | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Molecular & Cellular Oncology on 22/04/2016, available online: http://www.tandfonline.com/10.1080/23723556.2016.1162897 | |
| dc.subject | Cancer genome | en_US |
| dc.subject | intratumor heterogeneity | en_US |
| dc.subject | mathematical model | en_US |
| dc.subject | mutation rate | en_US |
| dc.subject | neutral expansion | en_US |
| dc.subject | site-frequency spectrum | en_US |
| dc.title | Functional versus non-functional intratumor heterogeneity in cancer. | en_US |
| dc.type | Article | |
| dc.rights.holder | (c) 2016 Taylor & Francis Group | |
| dc.identifier.doi | 10.1080/23723556.2016.1162897 | en_US |
| pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/27652316 | en_US |
| pubs.issue | 4 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published online | en_US |
| pubs.volume | 3 | en_US |
| dcterms.dateAccepted | 2016-03-02 | en_US |
