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    Functional versus non-functional intratumor heterogeneity in cancer. 
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    Functional versus non-functional intratumor heterogeneity in cancer.

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    Accepted version (41.80Kb)
    Volume
    3
    Pagination
    e1162897 - ?
    DOI
    10.1080/23723556.2016.1162897
    Journal
    Mol Cell Oncol
    Issue
    4
    ISSN
    2372-3556
    Metadata
    Show full item record
    Abstract
    Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.
    Authors
    Williams, MJ; Werner, B; Graham, TA; Sottoriva, A
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/15910
    Collections
    • Centre for Tumour Biology [350]
    Language
    eng
    Licence information
    This is an Accepted Manuscript of an article published by Taylor & Francis Group in Molecular & Cellular Oncology on 22/04/2016, available online: http://www.tandfonline.com/10.1080/23723556.2016.1162897
    Copyright statements
    (c) 2016 Taylor & Francis Group
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