| dc.contributor.author | De Rossi, G | en_US |
| dc.contributor.author | Whiteford, JR | en_US |
| dc.date.accessioned | 2016-08-17T13:21:21Z | |
| dc.date.available | 2013-12-09 | en_US |
| dc.date.issued | 2013 | en_US |
| dc.date.submitted | 2016-08-10T13:21:41.089Z | |
| dc.identifier.issn | 2046-1402 | en_US |
| dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/14730 | |
| dc.description.abstract | Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins of syndecan-1,-2 and -4 all possess adhesion regulatory motifs and we hypothesized that syndecan-3 may also possess such characteristics. Here we show that a bacterially expressed GST fusion protein consisting of the entire mature syndecan-3 ectodomain has anti-angiogenic properties and acts via modulating endothelial cell migration. This work identifies syndecan-3 as a possible therapeutic target for anti-angiogenic therapy. | en_US |
| dc.description.sponsorship | This work was funded by Arthritis Research-UK (Grant No. 19207) and funds from the William Harvey Research Foundation both to JRW. | en_US |
| dc.format.extent | 270 - ? | en_US |
| dc.language | eng | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | F1000Res | en_US |
| dc.title | A novel role for syndecan-3 in angiogenesis. | en_US |
| dc.type | Article | |
| dc.rights.holder | © 2013 De Rossi G and Whiteford JR. | |
| dc.rights.holder | This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). | |
| dc.identifier.doi | 10.12688/f1000research.2-270.v1 | en_US |
| pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/24555114 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published online | en_US |
| pubs.volume | 2 | en_US |
| dcterms.dateAccepted | 2013-12-09 | en_US |
