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dc.contributor.authorHaase, A-Men_US
dc.contributor.authorFallet, Sen_US
dc.contributor.authorOtto, Men_US
dc.contributor.authorScott, SMen_US
dc.contributor.authorSchlageter, Ven_US
dc.contributor.authorKrogh, Ken_US
dc.date.accessioned2016-05-27T16:00:48Z
dc.date.issued2015en_US
dc.date.submitted2016-05-24T20:20:48.290Z
dc.identifier.issn1178-7023en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/12592
dc.description.abstractStudies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric capsule system, which can be used in conjunction with polysomnography, offers a solution to this problem. The 3D-Transit system consists of ingestible electromagnetic capsules traceable through a portable extracorporeal receiver while traversing the gut. During sleep monitored by polysomnography, gastrointestinal motility was concurrently investigated using 3D-Transit in nine healthy subjects. Overall, the amplitude of gastric contractions decreased with depth of sleep (light sleep, N2 versus deep sleep, N3; P<0.05). Progression through the small intestine did not change with depth of sleep (Kruskal-Wallis probability =0.1), and there was no association between nocturnal awakenings or arousals and the occurrence of colonic or small intestinal propagating movements. Basal colonic activity was suppressed during both deep sleep (P<0.05) and light sleep (P<0.05) when compared with nocturnal wake periods. In conclusion, the novel ambulatory 3D-Transit system combined with polysomnography allows minimally invasive and completely ambulatory investigation of associations between sleep patterns and gastrointestinal motility.en_US
dc.format.extent327 - 332en_US
dc.languageengen_US
dc.language.isoenen_US
dc.relation.ispartofClin Exp Gastroenterolen_US
dc.rightsCC-BY-NC
dc.subjectcircadian motilityen_US
dc.subjectcolonic movementen_US
dc.subjectgastric contractionsen_US
dc.subjectingestible capsuleen_US
dc.subjectsleep assessmenten_US
dc.subjectsleep stageen_US
dc.titleGastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography - a pilot study.en_US
dc.typeArticle
dc.rights.holder© 2015 Haase et al.
dc.identifier.doi10.2147/CEG.S91964en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26677340en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.volume8en_US


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