Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography - a pilot study.
dc.contributor.author | Haase, A-M | en_US |
dc.contributor.author | Fallet, S | en_US |
dc.contributor.author | Otto, M | en_US |
dc.contributor.author | Scott, SM | en_US |
dc.contributor.author | Schlageter, V | en_US |
dc.contributor.author | Krogh, K | en_US |
dc.date.accessioned | 2016-05-27T16:00:48Z | |
dc.date.issued | 2015 | en_US |
dc.date.submitted | 2016-05-24T20:20:48.290Z | |
dc.identifier.issn | 1178-7023 | en_US |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/12592 | |
dc.description.abstract | Studies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric capsule system, which can be used in conjunction with polysomnography, offers a solution to this problem. The 3D-Transit system consists of ingestible electromagnetic capsules traceable through a portable extracorporeal receiver while traversing the gut. During sleep monitored by polysomnography, gastrointestinal motility was concurrently investigated using 3D-Transit in nine healthy subjects. Overall, the amplitude of gastric contractions decreased with depth of sleep (light sleep, N2 versus deep sleep, N3; P<0.05). Progression through the small intestine did not change with depth of sleep (Kruskal-Wallis probability =0.1), and there was no association between nocturnal awakenings or arousals and the occurrence of colonic or small intestinal propagating movements. Basal colonic activity was suppressed during both deep sleep (P<0.05) and light sleep (P<0.05) when compared with nocturnal wake periods. In conclusion, the novel ambulatory 3D-Transit system combined with polysomnography allows minimally invasive and completely ambulatory investigation of associations between sleep patterns and gastrointestinal motility. | en_US |
dc.format.extent | 327 - 332 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clin Exp Gastroenterol | en_US |
dc.rights | CC-BY-NC | |
dc.subject | circadian motility | en_US |
dc.subject | colonic movement | en_US |
dc.subject | gastric contractions | en_US |
dc.subject | ingestible capsule | en_US |
dc.subject | sleep assessment | en_US |
dc.subject | sleep stage | en_US |
dc.title | Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography - a pilot study. | en_US |
dc.type | Article | |
dc.rights.holder | © 2015 Haase et al. | |
dc.identifier.doi | 10.2147/CEG.S91964 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26677340 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 8 | en_US |