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    The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy. 
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    • The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy.
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    • William Harvey Research Institute
    • Centre for Experimental Medicine and Rheumatology (EMR)
    • The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy.
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    The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy.

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    Blighe The presence of disseminated tumour cells in the bone marrow is inversely related to circulating free DNA in plasma in breast cancer dormancy 2011 Published.pdf (355.4Kb)
    Volume
    106
    Pagination
    375 - 382
    DOI
    10.1038/bjc.2011.537
    Journal
    Br J Cancer
    Issue
    2
    Metadata
    Show full item record
    Abstract
    BACKGROUND: The aim of this study was to gain insight into breast cancer dormancy by examining different measures of minimal residual disease (MRD) over time in relation to known prognostic factors. METHODS: Sixty-four primary breast cancer patients on follow-up (a median of 8.3 years post surgery) who were disease free had sequential bone marrow aspirates and blood samples taken for the measurement of disseminated tumour cells (DTCs), circulating tumour cells (CTCs) by CellSearch and qPCR measurement of overlapping (96-bp and 291-bp) amplicons in circulating free DNA (cfDNA). RESULTS: The presence of CTCs was correlated with the presence of DTCs measured by immunocytochemistry (P=0.01) but both were infrequently detected. Increasing cfDNA concentration correlated with ER, HER2 and triple-negative tumours and high tumour grade, and the 291-bp amplicon was inversely correlated with DTCs measured by CK19 qRT-PCR (P=0.047). CONCLUSION: Our results show that breast cancer patients have evidence of MRD for many years after diagnosis despite there being no overt evidence of disease. The inverse relationship between bone marrow CK19 mRNA and the 291-bp amplicon in cfDNA suggests that an inverse relationship between a measure of cell viability in the bone marrow (DTCs) and cell death in the plasma occurs during the dormancy phase of breast cancer.
    Authors
    Payne, RE; Hava, NL; Page, K; Blighe, K; Ward, B; Slade, M; Brown, J; Guttery, DS; Zaidi, SAA; Stebbing, J
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/11173
    Collections
    • Centre for Experimental Medicine and Rheumatology (EMR) [388]
    Language
    eng
    Licence information
    CC-BY--NC-SA
    Copyright statements
    © 2011, Rights Managed by Nature Publishing Group
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