| dc.contributor.author | Shaw, PA | en_US |
| dc.contributor.author | Klausen, M | en_US |
| dc.contributor.author | Bradley, M | en_US |
| dc.date.accessioned | 2024-04-04T13:05:32Z | |
| dc.date.available | 2023-12-04 | en_US |
| dc.date.issued | 2024-01-02 | en_US |
| dc.identifier.issn | 1759-9954 | en_US |
| dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/95925 | |
| dc.description.abstract | A light-responsive polymer allowing the controlled release of camptothecin and the generation of reactive oxygen species (ROS) is reported. The polymer was prepared by controlled copolymerisation of water-soluble N,N-dimethyl acrylamide with a bromocoumarin methacrylate monomer. The lipophilic chemotherapy agent camptothecin was caged onto the coumarin unit via a photo-cleavable carbonate ester enabling light-triggered cargo release. The polymer showed good biocompatibility in the dark, and high cancer cell killing activity mediated both by the photo-release of camptothecin and ROS generation. | en_US |
| dc.format.extent | 54 - 58 | en_US |
| dc.language | eng | en_US |
| dc.relation.ispartof | Polym Chem | en_US |
| dc.rights | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given. | |
| dc.title | A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy. | en_US |
| dc.type | Article | |
| dc.identifier.doi | 10.1039/d3py01137b | en_US |
| pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38174055 | en_US |
| pubs.issue | 2 | en_US |
| pubs.notes | Not known | en_US |
| pubs.publication-status | Published online | en_US |
| pubs.volume | 15 | en_US |
| dcterms.dateAccepted | 2023-12-04 | en_US |
| rioxxterms.funder | Default funder | en_US |
| rioxxterms.identifier.project | Default project | en_US |
| qmul.funder | EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond::Engineering and Physical Sciences Research Council | en_US |
| qmul.funder | EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond::Engineering and Physical Sciences Research Council | en_US |
