RSS 1.0Chemistry and Biochemistry
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DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single- Molecule Control
(American Chemical Society, 2018-12)We present a strategy for the fabrication of biomimetic nanoarrays, based on the use of DNA origami, that permits the multivalent investigation of ligand–receptor molecule interactions in cancer cell spreading, with nanoscale ... -
Automated Fluorescence Lifetime Imaging High-Content Analysis of Förster Resonance Energy Transfer between Endogenously Labeled Kinetochore Proteins in Live Budding Yeast Cells.
(SAGE, 2019-01-10)We describe an open-source automated multiwell plate fluorescence lifetime imaging (FLIM) methodology to read out Förster resonance energy transfer (FRET) between fluorescent proteins (FPs) labeling endogenous kinetochore ... -
Bringing Functional Genomics into Focus
(Elsevier, 2016-09)Styles et al. develop an optimized method that combines high-content microscopy and automated phenotypic analysis with genome-wide yeast genetics to identify genes in DNA damage repair. -
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer.
(2018-10)Breast cancer can occur in either gender; however, it is rare in men, accounting for <1% of diagnosed cases. In a previous transcriptomic screen of male breast cancer (MBC) and female breast cancer (FBC) occurrences, we ... -
Rotaxane-Based Transition Metal Complexes: Effect of the Mechanical Bond on Structure and Electronic Properties.
(American Chemical Society, 2018-12-18)Early work by Sauvage revealed that mechanical bonding alters the stability and redox properties of their original catenane metal complexes. However, despite the importance of controlling metal ion properties for a range ... -
X-ray structural, functional and computational studies of the O 2 -sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe–4S] cluster
(Royal Society of Chemistry, 2018-06-05)The crystal structure of the Escherichia coli O2-sensitive C19G [NiFe]-hydrogenase-1 variant shows that the mutation results in a novel FeS cluster, proximal to the Ni–Fe active site. While the proximal cluster of the ... -
Estimating mortality rates of European ash (Fraxinus excelsior) under the ash dieback (Hymenoscyphus fraxineus) epidemic
(Wiley, 2018-12-04)The ash dieback epidemic, caused by the fungus Hymenoscyphus fraxineus, has been present in Europe for over 20 years and caused widespread damage and mortality in ash tree (Fraxinus excelsior) populations. Ash is a major ... -
Binding Pockets in Proteins Induced by Mechanical Stress.
(2018-12-10)We report the first observation of a pocket that opens as a result of a mechanical force applied to an Ig-like domain from the cardiac muscle. This previously unseen mechanism of pocket formation is revealed by molecular ... -
Low-temperature anharmonicity and symmetry breaking in the sodalite
(2018-11-21)©2018 Walter de Gruyter GmbH, Berlin/Boston 2018. The aluminosilicate iodide sodalite |Na8I2|[AlSiO4]6 was examined by temperature-dependent neutron time-of-flight powder diffraction from 5 K to 290 K and X-ray diffraction ... -
Water oxidation catalysed by quantum- sized BiVO4+
(2018-12-28) -
Challenges and Opportunities in DNA-based Asymmetric Catalysis
(Schweizerische Chemische Gesellschaft, 2018-09-01)
