dc.contributor.author | Sayegh, S | |
dc.contributor.author | Fantecelle, CH | |
dc.contributor.author | Laphanuwat, P | |
dc.contributor.author | Subramanian, P | |
dc.contributor.author | Rustin, MHA | |
dc.contributor.author | Gomes, DCO | |
dc.contributor.author | Akbar, AN | |
dc.contributor.author | Chambers, ES | |
dc.date.accessioned | 2024-02-14T11:47:22Z | |
dc.date.available | 2024-01-10 | |
dc.date.available | 2024-02-14T11:47:22Z | |
dc.date.issued | 2024-01-29 | |
dc.identifier.citation | Sayegh, S., Fantecelle, C. H., Laphanuwat, P., Subramanian, P., Rustin, M. H. A., Gomes, D. C. O., Akbar, A. N., & Chambers, E. S. (2024). Vitamin D3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing. Aging Cell, 00, e14093. https://doi.org/10.1111/acel.14093 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/94631 | |
dc.description.abstract | Vitamin D3 replacement in older insufficient adults significantly improves their antigen-specific varicella zoster virus (VZV) cutaneous immunity. However, the mechanisms involved in this enhancement of cutaneous immunity are not known. Here, we show for the first time that vitamin D3 blocks the senescence-associated secretory phenotype (SASP) production by senescent fibroblasts by partially inhibiting the p38 MAPK pathway. Furthermore, transcriptomic analysis of skin biopsies from older subjects after vitamin D3 supplementation shows that vitamin D3 inhibits the same inflammatory pathways in response to saline as the specific p38 inhibitor, losmapimod, which also enhances immunity in the skin of older subjects. Vitamin D3 supplementation therefore may enhance immunity during ageing in part by blocking p38 MAPK signalling and in turn inhibit SASP production from senescent cells in vivo. | en_US |
dc.format.extent | e14093 - ? | |
dc.language | eng | |
dc.publisher | Wiley Open Access | en_US |
dc.relation.ispartof | Aging Cell | |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |
dc.subject | SASP | en_US |
dc.subject | ageing | en_US |
dc.subject | p38 MAPK | en_US |
dc.subject | senescence | en_US |
dc.subject | skin | en_US |
dc.subject | vitamin D | en_US |
dc.title | Vitamin D3 inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. | |
dc.identifier.doi | 10.1111/acel.14093 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38287646 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2024-01-10 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |