Clone competition as a mechanism to reduce tumor formation.
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Embargoed until: 5555-01-01
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Embargoed until: 5555-01-01
Reason: Version not permitted.
Volume
56
Pagination
3307 - 3308
DOI
10.1016/j.devcel.2021.12.003
Journal
Dev Cell
Issue
Metadata
Show full item recordAbstract
With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.
Authors
Acha-Sagredo, A; Malanchi, I; Ciccarelli, FDCollections
- Centre for Cancer Prevention [1179]