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dc.contributor.authorFrancis, Fen_US
dc.contributor.authorRobertson, RCen_US
dc.contributor.authorBwakura-Dangarembizi, Men_US
dc.contributor.authorPrendergast, AJen_US
dc.contributor.authorManges, ARen_US
dc.date.accessioned2023-12-06T15:30:25Z
dc.date.available2022-11-06en_US
dc.date.issued2023-01en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/92699
dc.description.abstractSevere acute malnutrition (SAM) and human immunodeficiency virus (HIV) infection underlie a major proportion of the childhood disease burden in low- and middle-income countries. These diseases commonly co-occur and lead to higher risk of other endemic infectious diseases, thereby compounding the risk of mortality and morbidity. The widespread use of antibiotics as treatment and prophylaxis in childhood SAM and HIV infections, respectively, has reduced mortality and morbidity but canlead to increasing antibiotic resistance. Development of antibiotic resistance could render future infections untreatable. This review summarises the endemic co-occurrence of undernutrition, particularly SAM, and HIV in children, and current treatment practices, specifically WHO-recommended antibiotic usage. The risks and benefits of antibiotic treatment, prophylaxis and resistance are reviewed in the context of patients with SAM and HIV and associated sub-populations. Finally, the review highlights possible research areas and populations where antibiotic resistance progression can be studied to best address concerns associated with the future impact of resistance. Current antibiotic usage is lifesaving in complicated SAM and HIV-infected populations; nevertheless, increasing baseline resistance and infection remain a significant concern. In conclusion, antibiotic usage currently addresses the immediate needs of children in SAM and HIV endemic regions; however, it is prudent to evaluate the impact of antibiotic use on resistance dynamics and long-term child health.en_US
dc.format.extent106690 - ?en_US
dc.languageengen_US
dc.relation.ispartofInt J Antimicrob Agentsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAntibiotic Prophylaxis/Treatmenten_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectChild Healthen_US
dc.subjectHuman Immunodeficiency Virus Infectionsen_US
dc.subjectSevere Acute Malnutritionen_US
dc.subjectHumansen_US
dc.subjectChilden_US
dc.subjectInfanten_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectHIV Infectionsen_US
dc.subjectSevere Acute Malnutritionen_US
dc.titleAntibiotic use and resistance in children with severe acute malnutrition and human immunodeficiency virus infection.en_US
dc.typeArticle
dc.identifier.doi10.1016/j.ijantimicag.2022.106690en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36372343en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume61en_US
dcterms.dateAccepted2022-11-06en_US
qmul.funderMETA-SAM (Metagenomics and Metabolomics of Severe Acute Malnutrition)::Wellcome Trusten_US


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States