• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. 
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Translational Medicine & Therapeutics
    • Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation.
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Translational Medicine & Therapeutics
    • Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation.

    Publisher
    Elsevier/Science Direct
    ISSN
    10.1016/j.vph.2015.02.010
    1537-1891
    Metadata
    Show full item record
    Abstract
    Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg flavanols/day for 6 weeks) on blood pressure, heart rate, vascular function and platelet aggregation in men with pre-hypertension or mild hypertension. Vascular function was assessed by pulse wave analysis using radial artery applanation tonometry in combination with inhaled salbutamol (0.4 mg) to assess changes due to endothelium-dependent vasodilatation. HFDC did not significantly reduce blood pressure compared to baseline or LFDC. Heart rate was increased by LFDC compared to baseline, but not by HFDC. Vascular responses to salbutamol tended to be greater after HFDC. Platelet aggregation induced by collagen or the thromboxane analogue U46619 was unchanged after LFDC or HFDC, whereas both chocolates reduced responses to ADP and the thrombin receptor activator peptide, SFLLRNamide (TRAP6), relative to baseline. Pre-incubation of platelets with theobromine also attenuated platelet aggregation induced by ADP or TRAP6. We conclude that consumption of HFDC confers modest improvements in cardiovascular function. Platelet aggregation is modulated by a flavanol-independent mechanism that is likely due to theobromine.
    Authors
    Rull, G; Mohd-Zain, Z; Shiel, J; Lundberg, MH; Collier, DJ; Johnston, A; Warner, TD; Corder, R
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/7551
    Collections
    • Centre for Translational Medicine & Therapeutics [779]
    Language
    ENG
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.