dc.contributor.author | Xiang, Y | |
dc.contributor.author | Huang, G | |
dc.contributor.author | Shan, Z | |
dc.contributor.author | Pan, L | |
dc.contributor.author | Luo, S | |
dc.contributor.author | Yang, L | |
dc.contributor.author | Shi, L | |
dc.contributor.author | Li, Q | |
dc.contributor.author | Leslie, RD | |
dc.contributor.author | Zhou, Z | |
dc.date.accessioned | 2021-03-24T11:05:59Z | |
dc.date.available | 2015-07-17 | |
dc.date.available | 2021-03-24T11:05:59Z | |
dc.date.issued | 2015-12 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/70838 | |
dc.description.abstract | AIMS: Adult-onset autoimmune diabetes is prevalent in China, in contrast to childhood-onset type 1 diabetes mellitus. Islet autoantibodies are the most important immune biomarkers to diagnose autoimmune diabetes. We assayed four different islet autoantibodies in recently diagnosed adult non-insulin-requiring diabetes Chinese subjects to investigate the best antibody assay strategy for the correct diagnosis of these subjects. METHODS: LADA China study is a nation-wide multicenter study conducted in diabetes patients from 46 university-affiliated hospitals in China. Non-insulin-treated newly diagnosed adult diabetes patients (n = 2388) were centrally assayed for glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase-2 autoantibody (IA-2A), and zinc transporter 8 autoantibody (ZnT8A) by radioligand assay and insulin autoantibody (IAA) by microtiter plate radioimmunoassay. Clinical data were determined locally. RESULTS: Two hundred and six (8.63 %) subjects were autoantibody positive, of which GADA identified 5.78 % (138/2388) of the total, but only 67 % (138/206) of the autoimmune cases. IA-2A, ZnT8A, and IAA were found in 1.51, 1.84, and 1.26 % of the total study subjects, respectively. When assaying three islet autoantibodies, the most effective strategy was the combination of GADA, ZnT8A, and IAA, which could identify 92.2 % (190/206) autoimmune diabetes patients. The clinical data showed that those subjects with positive GADA had lower random C-peptide than autoantibody negative subjects (P < 0.05). CONCLUSIONS: As with Europeans, GADA is the dominant autoantibody in this form of autoimmune diabetes in China, but in contrast to Europeans, screening should include other diabetes-associated autoantibodies. | en_US |
dc.format.extent | 1121 - 1127 | |
dc.language | eng | |
dc.relation.ispartof | Acta Diabetol | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Glutamic acid decarboxylase antibody (GADA) | en_US |
dc.subject | Insulin autoantibody (IAA) | en_US |
dc.subject | Latent autoimmune diabetes of adults (LADA) | en_US |
dc.subject | Protein tyrosine phosphatase-2 antibody (IA-2A) | en_US |
dc.subject | Zinc transporter 8 autoantibody (ZnT8A) | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Asian Continental Ancestry Group | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Cation Transport Proteins | en_US |
dc.subject | China | en_US |
dc.subject | Diabetes Mellitus, Type 2 | en_US |
dc.subject | Female | en_US |
dc.subject | Glutamate Decarboxylase | en_US |
dc.subject | Humans | en_US |
dc.subject | Islets of Langerhans | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Prevalence | en_US |
dc.subject | Protein Phosphatase 2 | en_US |
dc.subject | Zinc Transporter 8 | en_US |
dc.title | Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00592-015-0799-8 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26239144 | en_US |
pubs.issue | 6 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 52 | en_US |
dcterms.dateAccepted | 2015-07-17 | |