dc.contributor.author | Sennikov, SV | |
dc.contributor.author | Krysov, SV | |
dc.contributor.author | Silkov, AN | |
dc.contributor.author | Injelevskaya, TV | |
dc.contributor.author | Kozlov, VA | |
dc.date.accessioned | 2020-12-03T10:39:53Z | |
dc.date.available | 2020-12-03T10:39:53Z | |
dc.date.issued | 2002-02-21 | |
dc.identifier.issn | 1043-4666 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/68975 | |
dc.description.abstract | It has previously been determined that erythroid cells of mice are capable of expressing such cytokines as interleukin (IL) 1 alpha and beta, IL-4, IL-6, interferon gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor beta (TGF-beta). It has been shown that glycophorin A(+) (GlA(+)) and antigen erythroblasts (AG-EB(+)) (both human erythroid cells of embryonic origin) are also capable of producing a series of cytokines such as IL-1 beta, IL-2, IL-4 and IL-6. The aim of this work was to study the capacity of erythroid cells from human embryonic liver to produce such cytokines as IFN-gamma, TGF-beta1, tumour necrosis factor alpha (TNF-alpha) and IL-10. The erythroid cells were isolated by means of antibodies specific to erythroblasts (GlA and AG-EB), as well as those from single erythroid colonies. The production level of some cytokines varies insignificantly under the action of erythropoietin (Epo) and quantitatively differs in GlA(+) and AG-EB(+) erythroid cells. Hence, the erythroid cells express IFN-gamma, TGF-beta1, TNF-alpha and IL-10. The erythroid cells could be involved through the production of these cytokines in the regulation of such processes as self-renewal, proliferation and differentiation of cells of other blood-forming sites. | en_US |
dc.format.extent | 221 - 225 | |
dc.language | eng | |
dc.relation.ispartof | Cytokine | |
dc.subject | Cells, Cultured | en_US |
dc.subject | Erythroid Precursor Cells | en_US |
dc.subject | Humans | en_US |
dc.subject | Interferon-gamma | en_US |
dc.subject | Interleukin-10 | en_US |
dc.subject | Liver | en_US |
dc.subject | Transforming Growth Factor beta | en_US |
dc.subject | Tumor Necrosis Factor-alpha | en_US |
dc.title | Production of IL-10, TNF-alpha, IFN-gamma, TGF-beta1 by different populations of erythroid cells derived from human embryonal liver. | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1006/cyto.2001.0975 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/11991675 | en_US |
pubs.issue | 4 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 17 | en_US |