Browsing Centre for Haemato-Oncology by Title
Now showing items 1-20 of 140
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Augmenting Autologous Stem Cell Transplantation to Improve Outcomes in Myeloma.
(2016-11)Consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT) is the standard of care for transplantation-eligible patients with multiple myeloma, based on randomized trials showing improved ... -
Autophagy mediates degradation of nuclear lamina
(2015-11-05) -
Cdk7: open questions beyond the prevailing model.
(2012-10-01) -
Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.
(2014-07)Pancreatic ductal adenocarcinoma is one of the deadliest carcinomas and is characterized by highly tumorigenic and metastatic cancer stem cells (CSC). CSCs evade available therapies, which preferentially target highly ... -
Clones assemble! The clonal complexity of blood during ontogeny and disease.
(2020-03)Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of ... -
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.
(2017-11-22)Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances ... -
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
(Rockefeller University Press, 2019-03-19)Epigenetic regulators, such as EZH2, are frequently mutated in cancer, and loss-of-function EZH2 mutations are common in myeloid malignancies. We have examined the importance of cellular context for Ezh2 loss during the ...
