dc.contributor.author | Zechendorf, E | |
dc.contributor.author | O'Riordan, CE | |
dc.contributor.author | Stiehler, L | |
dc.contributor.author | Wischmeyer, N | |
dc.contributor.author | Chiazza, F | |
dc.contributor.author | Collotta, D | |
dc.contributor.author | Denecke, B | |
dc.contributor.author | Ernst, S | |
dc.contributor.author | Müller-Newen, G | |
dc.contributor.author | Coldewey, SM | |
dc.contributor.author | Wissuwa, B | |
dc.contributor.author | Collino, M | |
dc.contributor.author | Simon, T-P | |
dc.contributor.author | Schuerholz, T | |
dc.contributor.author | Stoppe, C | |
dc.contributor.author | Marx, G | |
dc.contributor.author | Thiemermann, C | |
dc.contributor.author | Martin, L | |
dc.date.accessioned | 2020-08-21T14:08:13Z | |
dc.date.available | 2020-08-21T14:08:13Z | |
dc.date.issued | 2020-03-26 | |
dc.identifier.citation | JCI Insight. 2020;5(8):e131571.https://doi.org/10.1172/jci.insight.131571. | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/66502 | |
dc.description.abstract | Septic cardiomyopathy is a life-threatening organ dysfunction caused by sepsis. Ribonuclease 1 (RNase 1) belongs to a group of host-defense peptides that specifically cleave extracellular RNA (eRNA). The activity of RNase1 is inhibited by ribonuclease-inhibitor 1 (RNH1). The role of RNase 1 in septic cardiomyopathy and associated cardiac apoptosis, however, is completely unknown. Here, we showed that sepsis resulted in a significant increase in RNH1 and eRNA serum levels compared to those of healthy subjects (p < 0.05). Treatment with RNase 1 resulted in a significant decrease of apoptosis, induced by the intrinsic pathway, and TNF expression in murine cardiomyocytes exposed to either necrotic cardiomyocytes or serum of septic patients for 16 h (p < 0.05). Furthermore, treatment of septic mice with RNase 1 resulted in a reduction in cardiac apoptosis, TNF expression and septic cardiomyopathy (p < 0.05). These data demonstrate that eRNA plays a crucial role in the pathophysiology of the organ (cardiac) dysfunction in sepsis and RNase and RNH1 may be new therapeutic targets/strategies to reduce the cardiac injury and dysfunction caused by sepsis. | en_US |
dc.language | eng | |
dc.publisher | American Society for Clinical Investigation | en_US |
dc.relation.ispartof | JCI Insight | |
dc.subject | Anesthesiology | en_US |
dc.subject | Immunology | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Innate immunity | en_US |
dc.subject | Pharmacology | en_US |
dc.title | Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2020, American Society for Clinical Investigation. | |
dc.identifier.doi | 10.1172/jci.insight.131571 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32213712 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.publisher-url | http://doi.org/10.1172/jci.insight.131571 | |
dcterms.dateAccepted | 2020-03-12 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |