Show simple item record

dc.contributor.authorTie, CHen_US
dc.contributor.authorRowe, HMen_US
dc.date.accessioned2020-08-17T12:55:55Z
dc.date.available2017-06-19en_US
dc.date.issued2017-08en_US
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/66341
dc.description.abstractRetrotransposons tune immune reactivity in differentiated cells because when they are transcribed, their nucleic acids can be viewed as non-self leading to innate immune sensing. Most retrotransposons, however, are subject to transcriptional regulation by a multitude of epigenetic pathways, which have coevolved with them for millions of years. While a lot is known about the epigenetic control of retrotransposons in germ cells and early embryos, surprisingly little is understood about these pathways in adult tissues, particularly in human cells. Recent evidence suggests that retrotransposon repression persists in differentiated cells and is dynamic. Future insight into this topic may teach us how to reactivate or silence specific retrotransposon families, to promote anti-tumor immunity or dampen autoimmunity through epigenetic modulation.en_US
dc.format.extent28 - 33en_US
dc.languageengen_US
dc.relation.ispartofCurr Opin Virolen_US
dc.subjectAdulten_US
dc.subjectAnimalsen_US
dc.subjectCell Differentiationen_US
dc.subjectEpigenesis, Geneticen_US
dc.subjectGene Expression Regulationen_US
dc.subjectGenome, Humanen_US
dc.subjectHumansen_US
dc.subjectImmunityen_US
dc.subjectMiceen_US
dc.subjectRetroelementsen_US
dc.subjectTranscription, Geneticen_US
dc.titleEpigenetic control of retrotransposons in adult tissues: implications for immune regulation.en_US
dc.typeArticle
dc.identifier.doi10.1016/j.coviro.2017.06.007en_US
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28675832en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume25en_US
dcterms.dateAccepted2017-06-19en_US
qmul.funderEpigenetic pathways through which endogenous retroviruses regulate cellular genes in pluripotent cells::Wellcome Trusten_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record