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Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.

dc.contributor.authorShivakoti, R
dc.contributor.authorDalli, J
dc.contributor.authorKadam, D
dc.contributor.authorGaikwad, S
dc.contributor.authorBarthwal, M
dc.contributor.authorColas, RA
dc.contributor.authorMazzacuva, F
dc.contributor.authorLokhande, R
dc.contributor.authorDharmshale, S
dc.contributor.authorBharadwaj, R
dc.contributor.authorKagal, A
dc.contributor.authorPradhan, N
dc.contributor.authorDeshmukh, S
dc.contributor.authorAtre, S
dc.contributor.authorSahasrabudhe, T
dc.contributor.authorKakrani, A
dc.contributor.authorKulkarni, V
dc.contributor.authorRaskar, S
dc.contributor.authorSuryavanshi, N
dc.contributor.authorChon, S
dc.contributor.authorGupte, A
dc.contributor.authorGupta, A
dc.contributor.authorGupte, N
dc.contributor.authorArriaga, MB
dc.contributor.authorFukutani, KF
dc.contributor.authorAndrade, BB
dc.contributor.authorGolub, JE
dc.contributor.authorMave, V
dc.date.accessioned2020-04-28T16:22:14Z
dc.date.available2019-11-08
dc.date.available2020-04-28T16:22:14Z
dc.date.issued2019-11-11
dc.identifier.citationShivakoti, R., et al. (2020). "Lipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes." Prostaglandins & Other Lipid Mediators 147: 106398.en_US
dc.identifier.issn1098-8823
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/63799
dc.description.abstractIndividuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution of inflammation) lipid mediators in individuals with TB and TB-DM. A nested cross-sectional study of 40 individuals (20 newly diagnosed DM and 20 without DM) was conducted within a cohort of individuals with active drug-susceptible treatment-naïve pulmonary TB. Lipid mediators were quantified in serum samples through lipid mediator profiling. We conducted correlation-based analysis of these mediators. Overall, the arachidonic acid-derived leukotriene and prostaglandin families were the most abundant pro-inflammatory lipid mediators, while lipoxins and maresins families were the most abundant pro-resolving lipid mediators in individuals with TB and TB-DM. Individuals with TB-DM had increased correlations and connectivity with both pro-inflammatory and pro-resolving lipid mediators compared to those with TB alone. We identified the most abundant lipid mediator metabolomes in circulation among individuals with TB and TB-DM; in addition, our data shows a substantial number of significant correlations between both pro-inflammatory and pro-resolving lipid mediators in individuals with TB-DM, delineating a molecular balance that potentially defines this comorbidity.en_US
dc.description.sponsorshipThis work was supported primarily by the United States National Institutes of Health (NIH), Bethesda, MD, USA (R01AI097494 to JG). Additional support for this work was obtained through Federal funds from the Government of India’s (GOI’s) Department of Biotechnology (DBT; New Delhi), the Indian Council of Medical Research (ICMR; New Delhi, India), the United States NIH, National Institute of Allergy and Infectious Diseases (NIAID), Office of AIDS Research (OAR), and distributed in part by CRDF Global (Arlington, VA, USA) (USB1-31147-XX13 CRDF/NIH to AG), and the NIH-funded Johns Hopkins Baltimore-Washington-India Clinical Trials Unit for NIAID Networks (U01AI069465 to VM, NG, AG). RS was supported by NIH/National Institute of Child Health and Human Development grant R00HD089753. RL was supported by the BJGMC JHU HIV TB Program funded by the Fogarty International Center, Bethesda, MD, USA (NIH grant D43TW009574). ANG was supported by NIH Research Training Grant # D43 TW009340 funded by the NIH Fogarty International Center, the National Institute of Neurological Disorders and Stroke, the National Institute of Mental Health, the National Heart, Lung, and Blood Institute and the National Institute of Environmental Health Sciences (Bethesda, MD, USA). BBA was supported by Intramural research program from FIOCRUZ and from the National Institutes of Health (U01AI115940) and NIH/CRDF RePORT International Supplemental Funds. BBA is a senior investigator from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. KFF was supported by a postdoctoral fellowship from the CNPq, Brazil. MBA was supported by a PhD fellowship from the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). JD is funded by European Research Council under the European Union’s Horizon 2020 research and innovation program (Grant 677542), a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant 107613/Z/15/Z), and the Barts Charity (Grant MGU0343). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the funders.en_US
dc.format.extent106398 - ?
dc.languageeng
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofProstaglandins Other Lipid Mediat
dc.rightsCC-NC ND
dc.subjectDiabetesen_US
dc.subjectInflammationen_US
dc.subjectLeukotrienesen_US
dc.subjectLipidsen_US
dc.subjectLipoxinsen_US
dc.subjectProstaglandinsen_US
dc.subjectResolvinsen_US
dc.subjectSpecialized pro-resolving mediatorsen_US
dc.subjectTuberculosisen_US
dc.titleLipid mediators of inflammation and Resolution in individuals with tuberculosis and tuberculosis-Diabetes.en_US
dc.typeArticleen_US
dc.rights.holder2019 Elsevier Inc.
dc.identifier.doi10.1016/j.prostaglandins.2019.106398
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31726221en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume147en_US
dcterms.dateAccepted2019-11-08
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US
qmul.funderSir Henry Dale Fellowship::Wellcome Trusten_US
qmul.funderSir Henry Dale Fellowship::Wellcome Trusten_US
qmul.funderSir Henry Dale Fellowship::Wellcome Trusten_US


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