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Re-personalization and stratification of hemophilia care in an evolving treatment landscape.

dc.contributor.authorHart, DP
dc.contributor.authorKessler, CM
dc.contributor.authorAledort, L
dc.date.accessioned2020-04-23T12:13:35Z
dc.date.available2020-04-23T12:13:35Z
dc.date.issued2019-11-11
dc.identifier.citationHart, D. P., et al. (2019). "Re-personalization and stratification of hemophilia care in an evolving treatment landscape." Hematology 24(1): 737-741.en_US
dc.identifier.issn1024-5332
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/63724
dc.description.abstractHemophilia therapeutics are evolving rapidly. Comprehensive care must also evolve to embrace this change. Online tools and guidelines are widely available to optimize prophylaxis with conventional clotting factor concentrates using an individual's predicted pharmacokinetic profile. Novel hemostatic agents (e.g. biphenotypic antibody) are also becoming widely available, with other agents with differing mechanisms of action in final stages of trial. Contemporary issues including challenges of prophylaxis; bleed treatment; laboratory monitoring and inhibitor risk/surveillance are summarized in this narrative review, focusing on how a re-personalization of education and treatment will be necessary to meet these challenges of the rapidly changing therapeutic landscape.en_US
dc.format.extent737 - 741
dc.languageeng
dc.language.isoenen_US
dc.publisherPublished by Informa UK Limited, trading as Taylor & Francis Groupen_US
dc.relation.ispartofHematology
dc.rightsCC-BY
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectHemophiliaen_US
dc.subjectcomprehensive careen_US
dc.subjectemicizumaben_US
dc.subjectfactoren_US
dc.subjectoptimizeen_US
dc.subjectpersonalizationen_US
dc.subjectpharmacokineticen_US
dc.subjectprophylaxisen_US
dc.titleRe-personalization and stratification of hemophilia care in an evolving treatment landscape.en_US
dc.typeArticleen_US
dc.rights.holder2019. The authors
dc.identifier.doi10.1080/16078454.2019.1687798
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31711380en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume24en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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