dc.contributor.author | Besa, EC | en_US |
dc.contributor.author | Chandwe, K | en_US |
dc.contributor.author | Banda, R | en_US |
dc.contributor.author | Munalula, L | en_US |
dc.contributor.author | Kalomo, L | en_US |
dc.contributor.author | Amadi, B | en_US |
dc.contributor.author | Kelly, P | en_US |
dc.date.accessioned | 2020-03-13T09:41:31Z | |
dc.date.issued | 2020-04 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/63159 | |
dc.description.abstract | OBJECTIVES: Glucagon-like peptide 2 (GLP-2) is a 33 amino acid peptide hormone released from enteroendocrine L-cells following nutrient ingestion. It has been shown to exert trophic effects on the gut. We set out to measure GLP-2 concentrations in blood in children with diarrhoea and malnutrition. METHODS: GLP-2 levels were measured in blood samples collected from 5 different groups of children (n = 324) at different time points: those with acute diarrhoea, during illness and 3 weeks after recovery; persistent diarrhoea and severe acute malnutrition; controls contemporaneous for diarrhoea; stunted children from the community; and controls contemporaneous for the stunted children. Stool biomarkers and pathogen analysis were carried out on the children with stunting. RESULTS: GLP-2 concentrations were higher during acute diarrhoea (median 3.1 ng/mL, interquartile range 2.1, 4.4) than on recovery (median 1.8, interquartile range 1.4, 3.1; P = 0.001), but were not elevated in children with persistent diarrhoea and severe acute malnutrition. In stunted children, there was a progressive decline in GLP-2 levels from 3.2 ng/mL (1.9, 4.9) to 1.0 (0.0, 2.0; P < 0.001) as the children became more stunted. Measures of seasonality (rainfall, temperature,Food Price Index, and Shiga toxin-producing Escherichia coli) were found to be significantly associated with GLP-2 concentrations in multivariable analysis. We also found a correlation between stool inflammatory biomarkers and GLP-2. CONCLUSIONS: In diarrhoea, GLP-2 levels increased in acute but not persistent diarrhoea. Malnutrition was associated with reduced concentrations. GLP-2 displayed seasonal variation consistent with variations in nutrient availability. | en_US |
dc.format.extent | 513 - 520 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | J Pediatr Gastroenterol Nutr | en_US |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 | |
dc.title | Glucagon-like Peptide 2 Concentrations Vary in Zambian Children During Diarrhoea, in Malnutrition and Seasonally. | en_US |
dc.type | Article | |
dc.rights.holder | © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology. | |
dc.identifier.doi | 10.1097/MPG.0000000000002633 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32044830 | en_US |
pubs.issue | 4 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 70 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Environmental enteropathy in Zambia: biomarkers defined by pathogenesis::Bill & Melinda Gates Foundation (BMGF ) | en_US |