dc.contributor.author | Niu, X | en_US |
dc.contributor.author | Luo, S | en_US |
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Xie, Z | en_US |
dc.contributor.author | Xiang, Y | en_US |
dc.contributor.author | Huang, G | en_US |
dc.contributor.author | Lin, J | en_US |
dc.contributor.author | Yang, L | en_US |
dc.contributor.author | Liu, Z | en_US |
dc.contributor.author | Wang, X | en_US |
dc.contributor.author | Leslie, RD | en_US |
dc.contributor.author | Zhou, Z | en_US |
dc.date.accessioned | 2019-10-04T17:01:20Z | |
dc.date.available | 2018-08-09 | en_US |
dc.date.issued | 2019-01 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/60010 | |
dc.description.abstract | BACKGROUND: Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic characteristics between elderly and young LADA patients. METHODS: The cross-sectional study included a total of 579 patients with LADA which was further divided into elderly LADA (E-LADA) group (n = 135, age of onset ≥60 years) and young LADA (Y-LADA) group (n = 444, age of onset <60 years). Age-matched subjects with type 2 diabetes were served as control (E-T2D group, n = 622). Clinical characteristics, serum autoantibodies, and HLA-DQ haplotypes were compared among these groups. RESULTS: Compared with patients with Y-LADA, patients with E-LADA have better residual beta-cell function and higher level of insulin resistance (both P < .01), more metabolic syndrome characteristics, similar proportion of islet autoantibody positivity, and strikingly different HLA-DQ genetic background. In comparison with E-T2D patients, E-LADA patients tend to have similar metabolic syndrome prevalence, comparable C-peptide levels, and insulin resistance levels and share similar HLA-DQ genetic characteristics. CONCLUSIONS: Elderly LADA differs phenotypically and genetically from Y-LADA but has a clinical and genetic profile more similar to that of E-T2D. These distinct phenotypes could potentially help physicians better manage patients with E-LADA. | en_US |
dc.format.extent | e3068 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Diabetes Metab Res Rev | en_US |
dc.rights | "This is the peer reviewed version of the following article: Niu, X, Luo, S, Li, X, et al. Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8. Diabetes Metab Res Rev. 2019; 35:e3068. https://doi.org/10.1002/dmrr.3068 which has been published in final form at https://doi.org/10.1002/dmrr.3068. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |
dc.subject | LADA | en_US |
dc.subject | class II antigens | en_US |
dc.subject | clinical characteristics | en_US |
dc.subject | latent autoimmune diabetes in adults | en_US |
dc.subject | metabolic syndrome | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Autoantibodies | en_US |
dc.subject | China | en_US |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Insulin Resistance | en_US |
dc.subject | Latent Autoimmune Diabetes in Adults | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Phenotype | en_US |
dc.title | Identification of a distinct phenotype of elderly latent autoimmune diabetes in adults: LADA China Study 8. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1002/dmrr.3068 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30160000 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 35 | en_US |
dcterms.dateAccepted | 2018-08-09 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |