dc.contributor.author | Gadsbøll, A-SØ | en_US |
dc.contributor.author | Jee, MH | en_US |
dc.contributor.author | Funch, AB | en_US |
dc.contributor.author | Alhede, M | en_US |
dc.contributor.author | Mraz, V | en_US |
dc.contributor.author | Weber, JF | en_US |
dc.contributor.author | Callender, LA | en_US |
dc.contributor.author | Carroll, EC | en_US |
dc.contributor.author | Bjarnsholt, T | en_US |
dc.contributor.author | Woetmann, A | en_US |
dc.contributor.author | Ødum, N | en_US |
dc.contributor.author | Thomsen, AR | en_US |
dc.contributor.author | Johansen, JD | en_US |
dc.contributor.author | Henson, SM | en_US |
dc.contributor.author | Geisler, C | en_US |
dc.contributor.author | Bonefeld, CM | en_US |
dc.date.accessioned | 2019-09-04T10:50:04Z | |
dc.date.available | 2019-07-16 | en_US |
dc.date.issued | 2019-09-10 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/59502 | |
dc.description.abstract | The skin is our interface with the outside world, and consequently it is exposed to a wide range of microbes and allergens. Recent studies have indicated that allergen-specific skin-resident memory T (TRM) cells play a role in allergic contact dermatitis (ACD). However, the composition and dynamics of the epidermal T-cell subsets during ACD are not known. Here we show that exposure of the skin to the experimental contact allergen DNFB results in a displacement of the normally occurring dendritic epidermal T cells (DETC) concomitant with an accumulation of epidermal CD8+CD69+CD103+ TRM cells in mice. By studying knockout mice, we provide evidence that CD8+ T cells are required for the displacement of the DETC and that DETC are not required for recruitment of CD8+ TRM cells to the epidermis following allergen exposure. We demonstrate that the magnitude of the allergic reaction correlates with the number of CD8+ epidermal TRM cells, which again correlates with allergen dose and number of allergen exposures. Finally, in an attempt to elucidate why CD8+ epidermal TRM cells persist in the epidermis, we show that CD8+ epidermal TRM cells have a higher proliferative capability and are bioenergetically more stable, displaying a higher spare respiratory capacity than DETC. | en_US |
dc.description.sponsorship | LEO Foundation | en_US |
dc.description.sponsorship | A.P. Møller Foundation for the Advancement of Medical Science | en_US |
dc.description.sponsorship | The Lundbeck Foundation | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | J Invest Dermatol | en_US |
dc.rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Pathogenic CD8+ Epidermis-Resident Memory T Cells Displace Dendritic Epidermal T Cells in Allergic Dermatitis. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1016/j.jid.2019.07.722 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31518559 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2019-07-16 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |