dc.contributor.author | Fosshaug, LE | en_US |
dc.contributor.author | Colas, RA | en_US |
dc.contributor.author | Anstensrud, AK | en_US |
dc.contributor.author | Gregersen, I | en_US |
dc.contributor.author | Nymo, S | en_US |
dc.contributor.author | Sagen, EL | en_US |
dc.contributor.author | Michelsen, A | en_US |
dc.contributor.author | Vinge, LE | en_US |
dc.contributor.author | Øie, E | en_US |
dc.contributor.author | Gullestad, L | en_US |
dc.contributor.author | Halvorsen, B | en_US |
dc.contributor.author | Hansen, TV | en_US |
dc.contributor.author | Aukrust, P | en_US |
dc.contributor.author | Dalli, J | en_US |
dc.contributor.author | Yndestad, A | en_US |
dc.date.accessioned | 2019-08-27T08:33:15Z | |
dc.date.available | 2019-07-09 | en_US |
dc.date.issued | 2019-08 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/59336 | |
dc.description.abstract | BACKGROUND: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating inflammatory disease. However, the regulation of these molecules following acute myocardial infarction (MI) remains of interest. METHODS: In this prospective observational study we aimed to profile plasma levels of SPMs in ST-elevation MI (STEMI) patients during the first week following MI. Plasma LM concentrations were measured in patients with STEMI (n = 15) at three time points and compared with stable coronary artery disease (CAD; n = 10) and healthy controls (n = 10). FINDINGS: Our main findings were: (i) Immediately after onset of MI and before peak troponin T levels, STEMI patients had markedly increased levels of SPMs as compared with healthy controls and stable CAD patients, with levels of these mediators declining during follow-up. (ii) The increase in SPMs primarily reflected an increase in docosapentaenoic acid- and docosahexaenoic acid-derived protectins. (iii) Several individual protectins were correlated with the rapid increase in neutrophil counts, but not with CRP. (iv) A shift in 5-LOX activity from the leukotriene B4 pathway to the pro-resolving RvTs was observed. INTERPRETATION: The temporal regulation of SPMs indicates that resolution mechanisms are activated early during STEMI as part of an endogenous mechanism to initiate repair. Thus strategies to boost the activity and/or efficacy of these endogenous mechanisms may represent novel therapeutic opportunities for treatment of patients with MI. FUND: This work was supported by grants from the South-Eastern Norwegian regional health authority, the European Research Council under the European Union's Horizon 2020 research and innovation program, a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society, and the Barts Charity. | en_US |
dc.description.sponsorship | South-Eastern Norwegian regional health authority (Helse Sør-Øst RHF) (Grant 2011101). | en_US |
dc.description.sponsorship | Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant 1047613/Z/15/Z) | en_US |
dc.description.sponsorship | European Union's Horizon 2020 research and innovation programme (grant no: 677542) | en_US |
dc.description.sponsorship | Barts Charity (Grant MGU0343) | en_US |
dc.format.extent | 264 - 273 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | EBioMedicine | en_US |
dc.rights | Creative Commons Attribution License (CC BY) | |
dc.subject | Inflammation | en_US |
dc.subject | Myocardial infarction | en_US |
dc.subject | Polyunsaturated fatty acids | en_US |
dc.subject | Resolution | en_US |
dc.subject | Specialized pro-resolving mediators | en_US |
dc.subject | Aged | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Inflammation Mediators | en_US |
dc.subject | Lipids | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Myocardial Infarction | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | ST Elevation Myocardial Infarction | en_US |
dc.title | Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1016/j.ebiom.2019.07.024 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31345784 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 46 | en_US |
dcterms.dateAccepted | 2019-07-09 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Sir Henry Dale Fellowship::Wellcome Trust | en_US |
qmul.funder | Sir Henry Dale Fellowship::Wellcome Trust | en_US |
qmul.funder | Sir Henry Dale Fellowship::Wellcome Trust | en_US |