dc.contributor.author | Aksoy, E | en_US |
dc.contributor.author | Saveanu, L | en_US |
dc.contributor.author | Manoury, B | en_US |
dc.date.accessioned | 2019-06-03T10:45:21Z | |
dc.date.available | 2018-11-11 | en_US |
dc.date.issued | 2018 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/57825 | |
dc.description.abstract | Phosphoinositide-3 kinases (PI3Ks) generate 3-phosphorylated phosphoinositide lipids that are implicated in many biological processes in homeostatic states and pathologies such as cancer, inflammation and autoimmunity. Eight isoforms of PI3K exist in mammals and among them the class I PI3K, p110γ, and PI3Kδ, and class III Vps34 being the most expressed and well characterized in immune cells. Following engagement of pathogen recognition receptors (PRRs), PI3Ks coordinate vital cellular processes of signaling and vesicular trafficking in innate phagocytes such as macrophages and professional antigen presenting dendritic cells (DCs). Although previous studies demonstrated the involvement of PI3K isoforms in innate and adaptive immune cell types, the role of PI3Ks with respect to DC biology has been enigmatic. Thus, this review, based on studies involving PI3K isoforms, highlight how the different PI3Ks isoforms could regulate DC functions such as antigen processing and presentation including PRR responses. | en_US |
dc.format.extent | 2574 - ? | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Front Immunol | en_US |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
dc.subject | PI3K | en_US |
dc.subject | antigen presentation | en_US |
dc.subject | dendritic cell | en_US |
dc.subject | phospholipids | en_US |
dc.subject | toll like receptors | en_US |
dc.subject | Adaptive Immunity | en_US |
dc.subject | Animals | en_US |
dc.subject | Antigen Presentation | en_US |
dc.subject | Autoimmune Diseases | en_US |
dc.subject | Dendritic Cells | en_US |
dc.subject | Humans | en_US |
dc.subject | Immunity, Innate | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Phosphatidylinositol 3-Kinases | en_US |
dc.subject | Protein Isoforms | en_US |
dc.subject | Receptors, Pattern Recognition | en_US |
dc.subject | Signal Transduction | en_US |
dc.title | The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. | en_US |
dc.type | Article | |
dc.rights.holder | © 2018 Aksoy, Saveanu and Manoury. | |
dc.identifier.doi | 10.3389/fimmu.2018.02574 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30498491 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 9 | en_US |
dcterms.dateAccepted | 2018-10-18 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
qmul.funder | The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.::Medical Research Council | en_US |
qmul.funder | The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.::Medical Research Council | en_US |
qmul.funder | The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.::Medical Research Council | en_US |