dc.contributor.advisor | 2017. The authors | |
dc.contributor.author | Kon, SSC | en_US |
dc.contributor.author | Jolley, CJ | en_US |
dc.contributor.author | Shrikrishna, D | en_US |
dc.contributor.author | Montgomery, HE | en_US |
dc.contributor.author | Skipworth, JRA | en_US |
dc.contributor.author | Puthucheary, Z | en_US |
dc.contributor.author | Moxham, J | en_US |
dc.contributor.author | Polkey, MI | en_US |
dc.contributor.author | Man, WD-C | en_US |
dc.contributor.author | Hopkinson, NS | en_US |
dc.date.accessioned | 2019-04-24T11:27:07Z | |
dc.date.available | 2017-01-13 | en_US |
dc.date.issued | 2017 | en_US |
dc.identifier.issn | 2052-4439 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/57002 | |
dc.description.abstract | INTRODUCTION: Skeletal muscle impairment is an important feature of chronic obstructive pulmonary disease (COPD). Renin-angiotensin system activity influences muscle phenotype, so we wished to investigate whether it affects the response to pulmonary rehabilitation. METHODS: Two studies are described; in the first, the response of 168 COPD patients (mean forced expiratory volume in one second 51.9% predicted) to pulmonary rehabilitation was compared between different ACE insertion/deletion polymorphism genotypes. In a second, independent COPD cohort (n=373), baseline characteristics and response to pulmonary rehabilitation were compared between COPD patients who were or were not taking ACE inhibitors or angiotensin receptor antagonists (ARB). RESULTS: In study 1, the incremental shuttle walk distance improved to a similar extent in all three genotypes; DD/ID/II (n=48/91/29) 69(67)m, 61 (76)m and 78 (78)m, respectively, (p>0.05). In study 2, fat free mass index was higher in those on ACE-I/ARB (n=130) than those who were not (n=243), 17.8 (16.0, 19.8) kg m-2 vs 16.5 (14.9, 18.4) kg/m2 (p<0.001). However change in fat free mass, walking distance or quality of life in response to pulmonary rehabilitation did not differ between groups. CONCLUSIONS: While these data support a positive association of ACE-I/ARB treatment and body composition in COPD, neither treatment to reduce ACE activity nor ACE (I/D) genotype influence response to pulmonary rehabilitation. | en_US |
dc.description.sponsorship | The study was funded by a Trevor Clay grant from The British Lung Foundation (TC 04/4) and supported by the NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield Hospital and Imperial College who part fund MIP’s salary. WD-CM is an NIHR Clinician Scientist and supported by a MRC New Investigator Research Grant. DS was funded by the MRC G0701628. ZP is a NIHR Doctorate Research Fellow. SSCK and CJJ were funded by the MRC | en_US |
dc.format.extent | e000165 - ? | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | BMJ Open Respir Res | en_US |
dc.rights | Creative Commons Attribution License | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | COPD Pathology | en_US |
dc.subject | Pulmonary Rehabilitation | en_US |
dc.title | ACE and response to pulmonary rehabilitation in COPD: two observational studies. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1136/bmjresp-2016-000165 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28321311 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 4 | en_US |
dcterms.dateAccepted | 2017-01-13 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |