Centre for Genomics and Child Health: Recent submissions
Now showing items 481-500 of 836
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FASN activity is important for the initial stages of the induction of senescence
(Springer Nature, 2019-04-08)Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is characterized ... -
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
(Elsevier Inc., 2019-01-17)Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare ... -
Correction to: Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data.
(2019-02-22)Following publication of the original article [1], it was reported that the incorrect "Additional file 3" was published. The correct additional file is given below. -
HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination.
(Elsevier, 2016-03-31)The number of infants infected with HIV is declining with the rise in interventions for the elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV through their HIV-infected mothers ... -
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK4a)
(Wiley Online, 2015-09-29)Polycomb repressive complexes (PRC1 and PRC2) are epigenetic regulators that act in coordination to influence multiple cellular processes including pluripotency, differentiation, cancer and senescence. The role of PRCs in ... -
Effectiveness of school-based self-management interventions for asthma among children and adolescents: findings from a Cochrane systematic review and meta-analysis.
(BMJ, 2019-01-27)INTRODUCTION: The evidence that teaching self-management techniques to children and young people with asthma in schools is effective has not, to date, been the subject of systematic review. METHODS: We conducted a systematic ... -
The impact of improved water, sanitation and hygiene on oral rotavirus vaccine immunogenicity in Zimbabwean infants: sub-study of a cluster-randomized trial.
(Oxford University Press for the Infectious Diseases Society of America., 2019-02-16)BACKGROUND: Oral vaccines have lower efficacy in developing compared to developed countries. Poor water, sanitation and hygiene (WASH) may contribute to reduced oral vaccine immunogenicity. METHODS: We conducted a ... -
The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production
(Elsevier/Science Direct, 2011-10-14)In this study, infective larvae of the parasitic helminth Schistosoma mansoni were shown to contain a large number of glycosylated components specific for the Mannose Receptor (MR; CD206), which is an important pattern ... -
Causal role of histone acetylations in enhancer function.
(Taylor & Francis, 2016-11-28)Enhancers control development and cellular function by spatiotemporal regulation of gene expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono methylation of histone H3 at lysine 4 (H3K4me1) ... -
An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway
(Public Library of Science, 2016-03-03)In invertebrates, small interfering RNAs are at the vanguard of cell-autonomous antiviral immunity. In contrast, antiviral mechanisms initiated by interferon (IFN) signaling predominate in mammals. Whilst mammalian IFN-induced ... -
CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
(Public Library of Science, 2014-08-07)Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total ... -
School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review.
(Wiley, 2019-01-28)BACKGROUND: Asthma is a common respiratory condition in children that is characterised by symptoms including wheeze, shortness of breath, chest tightness, and cough. Children with asthma may be able to manage their condition ... -
Transmission of CMV, HTLV-1, and HIV through breastmilk
(Elsevier, 2019-03-14)© 2019 Elsevier Ltd. Breastfeeding is a crucial child survival intervention. However, the potential for transmission of viral infections from mother to child presents the dilemma of how best to interpret the benefits and ... -
Role of tumour necrosis factor receptor 5 in glucolipotoxic islet cell death
(Wiley, 2017-03-08)Abstract P39 from Abstracts of the Diabetes UK Professional Conference 2017, Manchester Central, Manchester, 8–10 March 2017