Centre for Genomics and Child Health: Recent submissions
Now showing items 401-420 of 836
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The Anti-inflammatory Effects of Cotrimoxazole Prophylaxis for People Living With Human Immunodeficiency Virus in Sub-Saharan Africa.
(Oxford University Press, 2019-10-23)Cotrimoxazole prophylaxis reduces morbidity and mortality among people living with human immunodeficiency virus (HIV) in sub-Saharan Africa, regardless of age, degree of immunosuppression, disease stage, or duration ... -
Intracerebral haemorrhage in Down syndrome: protected or predisposed?
(F1000Research, 2016-05-12)Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the ... -
Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh
(BMC (part of Springer Nature), 2019-11-11)Background To assess the maternal characteristics and nutritional status according to body mass index (BMI) at 6–14 weeks of gestation and to examine the relationship between maternal nutritional status in early pregnancy ... -
Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease.
(Elsevier, 2020-01-20)BACKGROUND: The World Health Organization estimates that air pollution is responsible for 7 million deaths per annum, with 7% of these attributable to pneumonia. Many of these fatalities have been linked to exposure to ... -
Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.
(2020-03-24)By sequencing autozygous human populations we identified a healthy adult woman with lifelong complete knockout of HAO1 (expected ~1 in 30 million outbred people). HAO1 (glycolate oxidase) silencing is the mechanism of ... -
The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement.
(2019-08-28)BACKGROUND: Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only ... -
Lung health and exposure to air pollution in Malawian children (CAPS): a cross-sectional study.
(2019-11)BACKGROUND: Non-communicable lung disease and exposure to air pollution are major problems in sub-Saharan Africa. A high burden of chronic respiratory symptoms, spirometric abnormalities and air pollution exposures has ... -
The United Kingdom National Neonatal Research Database: A validation study.
(2018)BACKGROUND: The National Neonatal Research Database (NNRD) is a rich repository of pre-defined clinical data extracted at regular intervals from point-of-care, clinician-entered electronic patient records on all admissions ... -
Impact of Water Quality, Sanitation, Handwashing, and Nutritional Interventions on Enteric Infections in Rural Zimbabwe: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial.
(2020-03-28)BACKGROUND: We assessed the impact of water, sanitation, and hygiene (WASH) and infant and young child feeding (IYCF) interventions on enteric infections in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial ...