Centre for Genomics and Child Health: Recent submissions
Now showing items 381-400 of 836
-
Crossroads between transposons and gene regulation
(2020-03-30) -
NPI-0052 and γ-radiation induce a synergistic apoptotic effect in medulloblastoma.
(Nature Research (part of Springer Nature), 2019-10-16)Medulloblastoma (MB) is the most common malignant solid paediatric brain tumour. The standard treatment for MB is surgical resection of the tumour, radiation and chemotherapy. This therapy is associated with high morbidity ... -
Commentaries on Viewpoint: "Muscle memory" not mediated by myonuclear number? Secondary analysis of human detraining data.
(American Physiological Society, 2019-12-01) -
Mortality, HIV transmission and growth in children exposed to HIV in rural Zimbabwe.
(2020-01-24)BACKGROUND: Although prevention of mother-to-child transmission (PMTCT) interventions have substantially reduced vertical HIV infection in sub-Saharan Africa, mortality and growth among children who are HIV-exposed remain ... -
Predictors of oral rotavirus vaccine immunogenicity in rural Zimbabwean infants.
(Elsevier, 2020-03-17)BACKGROUND: Oral rotavirus vaccines (RVV) have poor immunogenicity in low-income countries, for reasons that remain unclear. This study identified the determinants of RVV immunogenicity among infants in rural Zimbabwe. ... -
Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma.
(Springer Nature, 2020-03-19)Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel ... -
A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome
(Springer Nature, 2020-01-17)Purpose: To investigate if specific exon 38 or 39 KMT2D missense variants (MVs) cause a condition distinct from Kabuki syndrome type 1 (KS1). Methods: Multiple individuals, with MVs in exons 38 or 39 of KMT2D that ... -
Airway dendritic cell maturation in children exposed to air pollution.
(Public Library of Science (PLoS), 2020)Urban particulate matter (PM) enhances airway dendritic cell (DC) maturation in vitro. However, to date, there are no data on the association between exposure to urban PM and DC maturation in vivo. We sought to determine ... -
Towards standardisation of evidence-based clinical care process specifications.
(SAGE, 2020-03-18)There is a strong push towards standardisation of treatment approaches, care processes and documentation of clinical practice. However, confusion persists regarding terminology and description of many clinical care process ... -
A Cleaner Burning Biomass-Fueled Cookstove Intervention To Prevent Pneumonia In Children Under 5 Years Old In Rural Malawi (caps): A Cluster Randomised Controlled Trial
(Elsevier, 2017-01-14)Background WHO estimates exposure to air pollution from cooking with solid fuels is associated with over 4 million premature deaths worldwide every year including half a million children under the age of 5 years from ... -
Moving towards transformational WASH Reply
(Elsevier, 2019-11)We agree with Karen Levy and Joseph Eisenberg that observational studies of water, sanitation, and hygiene (WASH) interventions with carefully designed counterfactuals can play a valuable role in generating evidence on ... -
Biomass Smoke and Infection: Mechanisms of Interaction
(2011-01-01)© 2011 Elsevier B.V. All rights reserved. The mechanisms underlying the association between exposure to air pollution and vulnerability to infection remain to be fully defined. However, both animal and in vitro studies ...