Browsing Centre for Genomics and Child Health by Title
Now showing items 579-598 of 835
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The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity.
(Elsevier, 2023-10-02)Our understanding of how STAG proteins contribute to cell identity and disease have largely been studied from the perspective of chromosome topology and protein-coding gene expression. Here, we show that STAG1 is the ... -
Near-fatal and fatal asthma and air pollution: are we missing an opportunity to ask key questions?
(2023-11-10)There is an increasing body of evidence supporting the link between asthma attacks and air pollution in children. To our knowledge, there has only been one reported case of a fatal asthma attack in a child associated with ... -
Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants.
(2018-12-20)Background: Micronutrient deficiencies may contribute to reduced oral vaccine immunogenicity in developing countries. We hypothesised that neonatal vitamin A supplementation (NVAS) would improve oral vaccine responses. ... -
Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome.
(2018-04-10)BACKGROUND: Down syndrome (DS) may be considered a genetic form of Alzheimer's disease (AD) due to universal development of AD neuropathology, but diagnosis and treatment trials are hampered by a lack of reliable blood ... -
Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects.
(2021-04-21)INTRODUCTION: Hepatitis B virus (HBV) causes a complex and persistent infection with a major impact on patients health. Viral-genome sequencing can provide valuable information for characterizing virus genotype, infection ... -
NPI-0052 and γ-radiation induce a synergistic apoptotic effect in medulloblastoma.
(Nature Research (part of Springer Nature), 2019-10-16)Medulloblastoma (MB) is the most common malignant solid paediatric brain tumour. The standard treatment for MB is surgical resection of the tumour, radiation and chemotherapy. This therapy is associated with high morbidity ... -
Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
(2017-01)BACKGROUND: Neurodevelopment is strongly influenced by maternal and early-postnatal diet. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are vital structural and functional components of the developing brain. The gut ...