New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
10495 - ?
MetadataShow full item record
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
AuthorsLu, Y; Day, FR; Gustafsson, S; Buchkovich, ML; Na, J; Bataille, V; Cousminer, DL; Dastani, Z; Drong, AW; Esko, T; Evans, DM; Falchi, M; Feitosa, MF; Ferreira, T; Hedman, ÅK; Haring, R; Hysi, PG; Iles, MM; Justice, AE; Kanoni, S; Lagou, V; Li, R; Li, X; Locke, A; Lu, C; Mägi, R; Perry, JR; Pers, TH; Qi, Q; Sanna, M; Schmidt, EM; Scott, WR; Shungin, D; Teumer, A; Vinkhuyzen, AA; Walker, RW; Westra, HJ; Zhang, M; Zhang, W; Zhao, JH; Zhu, Z; Afzal, U; Ahluwalia, TS; Bakker, SJ; Bellis, C; Bonnefond, A; Borodulin, K; Buchman, AS; Cederholm, T; Choh, AC; Choi, HJ; Curran, JE; de Groot, LC; De Jager, PL; Dhonukshe-Rutten, RA; Enneman, AW; Eury, E; Evans, DS; Forsen, T; Friedrich, N; Fumeron, F; Garcia, ME; Gärtner, S; Han, BG; Havulinna, AS; Hayward, C; Hernandez, D; Hillege, H; Ittermann, T; Kent, JW; Kolcic, I; Laatikainen, T; Lahti, J; Mateo Leach, I; Lee, CG; Lee, JY; Liu, T; Liu, Y; Lobbens, S; Loh, M; Lyytikäinen, LP; Medina-Gomez, C; Michaëlsson, K; Nalls, MA; Nielson, CM; Oozageer, L; Pascoe, L; Paternoster, L; Polašek, O; Ripatti, S; Sarzynski, MA; Shin, CS; Narančić, NS; Spira, D; Srikanth, P; Steinhagen-Thiessen, E; Sung, YJ; Swart, KM; Taittonen, L; Tanaka, T; et al.
- Genomic Medicine