Browsing Centre for Genomics and Child Health by Title
Now showing items 85-104 of 835
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Calibrating models of cancer invasion: parameter estimation using approximate Bayesian computation and gradient matching.
(2021-06-16)We present two different methods to estimate parameters within a partial differential equation model of cancer invasion. The model describes the spatio-temporal evolution of three variables-tumour cell density, extracellular ... -
Can Breastfeeding Protect Against Antimicrobial Resistance?
Background: The proportion of infections among young children that are antimicrobial-resistant is increasing across the globe. Newborns may be colonized with enteric antimicrobial-resistant pathogens early in life, which ... -
Carbonaceous particulate matter on the lung surface from adults living in São Paulo, Brazil.
(2017)OBJECTIVES: We therefore sought to identify the exposures associated with lung surface in long-term residents of São Paulo, Brazil. METHODS: Lung surface carbon were analyzed in 72 autopsy specimens by image analysis. ... -
Causal role of histone acetylations in enhancer function.
(Taylor & Francis, 2016-11-28)Enhancers control development and cellular function by spatiotemporal regulation of gene expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono methylation of histone H3 at lysine 4 (H3K4me1) ... -
Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY Trial.
(Oxford University Press (OUP), 2018-03-04)Background: In sub-Saharan Africa, 20%-25% of people starting antiretroviral therapy (ART) have severe immunosuppression; approximately 10% die within 3 months. In the Reduction of EArly mortaLITY (REALITY) randomized ... -
Causes of impaired oral vaccine efficacy in developing countries.
(2018-01)Oral vaccines are less immunogenic when given to infants in low-income compared with high-income countries, limiting their potential public health impact. Here, we review factors that might contribute to this phenomenon, ... -
CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK4a)
(Wiley Online, 2015-09-29)Polycomb repressive complexes (PRC1 and PRC2) are epigenetic regulators that act in coordination to influence multiple cellular processes including pluripotency, differentiation, cancer and senescence. The role of PRCs in ... -
CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
(Public Library of Science, 2014-08-07)Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total ... -
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
(Springer Nature, 2023-12-15)Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer's disease (AD) is of great importance for the rational design of preventative therapies. Here we report a set of methods for the ...