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    Carbonaceous particulate matter on the lung surface from adults living in São Paulo, Brazil. 
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    Carbonaceous particulate matter on the lung surface from adults living in São Paulo, Brazil.

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    Published version (27.57Mb)
    Volume
    12
    Pagination
    e0188237 - ?
    DOI
    10.1371/journal.pone.0188237
    Journal
    PLoS One
    Issue
    11
    Metadata
    Show full item record
    Abstract
    OBJECTIVES: We therefore sought to identify the exposures associated with lung surface in long-term residents of São Paulo, Brazil. METHODS: Lung surface carbon were analyzed in 72 autopsy specimens by image analysis. Smoking history, measured PM10 nearest to the home, distance to main road, and distance-weighted traffic density were used as exposure variables. Data are summarized as median (IQR), and compared by Mann Whitney Test, with correlations done by Spearman's correlation. RESULTS: There was no association between lung surface and age or gender. There was no statistically significant association in lung surface between smokers and non-smokers 6.74 cm2 (3.47 to 10.02) versus 5.20cm2 (2.29 to 7.54), and there was no significant association between lung surface carbon and exposure to environmental PM and markers of traffic exposure. CONCLUSION: We did not find a statistically significant association between lung surface and smokers and non-smokers, and no statistically significant association between lung surface carbon and environmental exposure variables. These results suggest that lung surface carbon in long-term residents of São Paulo may predominately be from environmental PM, but the most appropriate environmental exposure marker remains unclear.
    Authors
    Padovan, MG; Whitehouse, A; Gouveia, N; Habermann, M; Grigg, J
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/34990
    Collections
    • Genomic Medicine [226]
    Language
    eng
    Licence information
    Creative Commons Attribution License
    Copyright statements
    2017 Padovan et al.
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