Browsing Centre for Genomics and Child Health by Title
Now showing items 649-668 of 835
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Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
(Nature Research, 2021-11-10) -
Predictors of oral rotavirus vaccine immunogenicity in rural Zimbabwean infants.
(Elsevier, 2020-03-17)BACKGROUND: Oral rotavirus vaccines (RVV) have poor immunogenicity in low-income countries, for reasons that remain unclear. This study identified the determinants of RVV immunogenicity among infants in rural Zimbabwe. ... -
Preschool wheeze, genes and treatment.
(2018-09)Preschool wheeze is a common but poorly understood cause of respiratory morbidity that is both distinct from and overlaps with infantile bronchiolitis and school age asthma. Attempts at classification by epidemiology, ... -
The presence of air pollution particulate matter in cryopreserved placental tissue cells.
(2021-07)Carbonaceous particles seen in frozen human macrophage-enriched placental cells can be used as a biomarker of personal exposure to combustion-derived particulate matter. The feasibility of using frozen tissues will allow ... -
Primary prevention of ROP and the oxygen saturation targeting trials.
(2019-10)Reducing the burden of visual morbidity from retinopathy of prematurity (ROP) begins with primary prevention, and improvements in neonatal care with a positive impact on ROP are possible in all settings. Strategies range ... -
Profiling DNA Methylation and Hydroxymethylation at Retrotransposable Elements.
(2016)DNA methylation is a key epigenetic modification controlling the transcriptional activity of mammalian retrotransposable elements. Its oxidation to DNA hydroxymethylation has been linked to DNA demethylation and reactivation ... -
Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
(Nature Publishing Group, 2012-06-26)Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human ... -
The proteome of neurofilament-containing protein aggregates in blood.
(Elsevier/Science Direct, 2018-05-25)Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. Recent observations suggest that ... -
Prothrombin Complex Concentrates versus Fresh Frozen Plasma in adult patients who are Undergoing Heart Surgery (PROPHESY) - A pilot randomized controlled trial with an evaluation of haemostatic potential
There is equipoise regarding the use of prothrombin complex concentrate vs. fresh frozen plasma in bleeding patients undergoing cardiac surgery. We performed a pilot randomised controlled trial to determine the recruitment ... -
A public health emergency among young people.
(2020-03)