Centre for Immunobiology: Recent submissions
Now showing items 41-60 of 1121
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Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC a randomised controlled trial
(European Respiratory Society, 2023-12-22)BACKGROUND: Short term studies suggest that dietary nitrate supplementation may improve cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial ... -
Cross-tissue immune cell analysis reveals tissue-specific features in humans
(American Association for the Advancement of Science, 2022-05-13) -
Immature platelet dynamics are associated with clinical outcomes after major trauma.
(2023-12-13)BACKGROUND: Major trauma results in dramatic changes in platelet behavior. Newly formed platelets are more reactive than older platelets, but their contributions to hemostasis and thrombosis after severe injury have not ... -
B cells defined by immunoglobulin isotypes
(Oxford University Press, 2022-10-05) -
Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling
(American Heart Association, 2023-01-26)Background: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. Despite extensive epidemiological ... -
Epigenetic and metabolic reprogramming of fibroblasts in Crohn's disease strictures reveals histone deacetylases as therapeutic targets.
(2023-12-09)BACKGROUND & AIMS: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease [CD]. We characterised fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis ... -
Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation
(Wiley, 2023-11-16)Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age-linked damage to amino acid sequence NGR (Asn-Gly-Arg) results in "gain-of-function" ... -
Mucosal Immunity to Gut Fungi in Health and Inflammatory Bowel Disease
(MDPI, 2023-11-14)The gut microbiome is a diverse microbial community composed of bacteria, viruses, and fungi that plays a major role in human health and disease. Dysregulation of these gut organisms in a genetically susceptible host is ... -
Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies.
(2023-01)Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial drugs for several months. The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb, the causative agent) together with ... -
Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories.
(2023-11-27)BACKGROUND & AIMS: Hepatitis delta virus (HDV) is a satellite RNA virus that requires the hepatitis B virus (HBV) for assembly and propagation. Individuals infected with HDV progress to advanced liver disease faster than ... -
Illustrated Abstracts of the 5th EUPLAN International Conference.
(2023-10)These illustrated capsules have been prepared by some speakers of State-of-the-Art talks and of original investigations, presented at the 5th European Platelet Network (EUPLAN) International Conference, which was held at ... -
Vitamin D supplements for fracture prevention in schoolchildren in Mongolia: analysis of secondary outcomes from a multicentre, double-blind, randomised, placebo-controlled trial.
(Elsevier, 2023-12-01)BACKGROUND: Vitamin D supplementation has been shown to increase total hip areal bone mineral density in healthy children and adolescents. We aimed to investigate whether supplementing schoolchildren living in Mongolia ... -
Chronic rhinosinusitis with nasal polyps: eosinophils versus B lymphocytes in disease pathogenesis.
(2024-02-01)PURPOSE OF REVIEW: To highlight the current evidence that supports the view that eosinophils may not drive disease in chronic rhinosinusitis with nasal polyps (CRSwNP) and the emerging evidence for B cells as an important ... -
2212. Cessation of fluoroquinolone prophylaxis in inpatients with haematological malignancy – a retrospective cohort analysis
(Oxford University Press (OUP), 2023-11-27)