Centre for Immunobiology: Recent submissions
Now showing items 381-400 of 1121
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The Specificity of TRIM5α-Mediated Restriction Is Influenced by Its Coiled-Coil Domain
(American Society for Microbiology, 2010-06-01)ABSTRACT: Retroviruses are both powerful evolutionary forces and dangerous threats to genome integrity. As such, they have imposed strong selective pressure on their hosts, notably triggering the emergence of restriction ... -
Homology-based Identification of Capsid Determinants That Protect HIV1 from Human TRIM5α Restriction
(American Society for Biochemistry & Molecular Biology (ASBMB), 2011-03-11) -
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells
The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. ... -
Drosha cuts the tethers of myelopoiesis
(Nature Research, 2015-11) -
Antiviral RNA Interference in Mammalian Cells
(American Association for the Advancement of Science (AAAS), 2013-10-11) -
Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study.
(2020-07-28)Cirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS. Transient ... -
Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic.
(BMJ, 2020)Objective: To determine the challenges in diagnosis, monitoring, support provision in the management of inflammatory bowel disease (IBD) patients and explore the adaptations of IBD services. Methods: Internet-based survey ... -
Week 96 results of a phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients
(Wolters Kluwer Health, Inc, 2020-04-01) -
Protocol for a multinational risk-stratified randomised controlled trial in paediatric Crohn's disease: methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or high risk for aggressive disease course.
(2020-07-01)INTRODUCTION: Immunomodulators such as thiopurines (azathioprine (AZA)/6-mercaptopurine (6MP)), methotrexate (MTX) and biologics such as adalimumab (ADA) are well established for maintenance of remission within paediatric ... -
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s.
(2020-11-03)The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes ...