Centre for Immunobiology: Recent submissions
Now showing items 1-20 of 1121
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Identification of RNF213 as a Potential Suppressor of Local Invasion in Intrahepatic Cholangiocarcinoma.
(Elsevier, 2024-05-06)Intrahepatic cholangiocarcinoma (ICC) is a lethal cancer with poor survival especially when it spreads. The histopathology of its rare intraductal papillary neoplasm of the bile duct type (IPNB) characteristically shows ... -
Single-cell RNA sequencing reveals the expansion of circulating tissue-homing B cell subsets in secondary acute dengue viral infection.
(Elsevier, 2024-05-30)The roles of antibodies secreted by subsets of B cells in dengue virus (DENV) infection have been extensively studied, yet, the contribution of tissue-homing B cells to antiviral immunity remains unclear. In this study, ... -
Prevention of sexual transmission of mpox: a systematic review and qualitative evidence synthesis of approaches.
(Taylor & Francis, 2024-07-03)BACKGROUND: The ongoing multi-country mpox outbreak in previously unaffected countries is primarily affecting sexual networks of men who have sex with men. Evidence is needed on the effectiveness of recommended preventive ... -
Rationale and design of the Self-TI Study protocol: a cross-sectional human papillomavirus self-testing pilot study among transgender adults in England
(BMJ Publishing Group, 2024-07-04)Introduction Persistent infection with high-risk human papillomavirus (HPV) is the causal agent of several cancers including cervical, anal and oropharyngeal cancer. Transgender men and transmasculine non-binary (TMNB) ... -
HOW ARE WE MANAGING NON-TUBERCULOUS MYCOBACTERIA PULMONARY DISEASE (NTM-PD)? RESULTS FROM THE FIRST UK-WIDE SURVEY OF CLINICAL PRACTICE
(BMJ Publishing Group, 2021-11-08) -
Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis.
(BMJ Publishing Group, 2024-04-04)OBJECTIVE: To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. DESIGN: Systematic review and meta-analysis. DATA ... -
Extrapulmonary nontuberculous mycobacterial infections: a guide for the general physician.
(Elsevier, 2024-02-12)Non-tuberculous mycobacteria (NTM) infections predominantly present as pulmonary disease. Although relatively rare, 20-30 % originate from extrapulmonary sites resulting in a wide range of clinical syndromes. Immunocompromised ... -
Barriers and enablers to the effective implementation of omics research in low- and middle-income countries.
(Nature Research, 2024-06-17) -
Multicentre service evaluation of injectable cabotegravir and rilpivirine delivery and outcomes across 12 UK clinics (SHARE LAI-net)
(Wiley, 2024-06-10)Introduction Long-acting injectable cabotegravir + rilpivirine (CAB + RPV LAI) was approved for use in virally suppressed adults in the England and Wales national health service in November 2021. We describe a service ... -
MAVMET trial: maraviroc and/or metformin for metabolic dysfunction-associated fatty liver disease(MAFLD) in adults with suppressed HIV.
(2024-05-31)OBJECTIVE: Metabolic dysfunction-associated fatty liver disease (MAFLD) is over-represented in people living with HIV (PLWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and ... -
A wireless semi-wearable sensor for assessment of gut function in low-resource settings
(SPIE, the international society for optics and photonics, 2024-03-13)Environmental enteric dysfunction (EED) is a subclinical disorder of intestinal function common in tropical countries and settings of poverty and economic disadvantage. EED manifests during infancy and is associated with ... -
The role of circulating T cells with a tissue resident phenotype (ex-TRM) in health and disease
(Frontiers, 2024-05-16)Tissue-resident memory T cells (TRM) are long-lived memory lymphocytes that persist in non-lymphoid tissues and provide the first line of defence against invading pathogens. They adapt to their environment in a tissue-specific ... -
P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel disease
(Oxford University Press (OUP), 2024-01-24) -
γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.
(2024-01)Stable microbial colonization of the skin depends on tight control by the host immune system. The lipid-dependent yeast Malassezia typically colonizes skin as a harmless commensal and is subject to host type 17 immunosurveillance, ... -
Refining DNA Barcoding Coupled High Resolution Melting for Discrimination of 12 Closely Related Croton Species.
(2015)DNA barcoding coupled high resolution melting (Bar-HRM) is an emerging method for species discrimination based on DNA dissociation kinetics. The aim of this work was to evaluate the suitability of different primer sets, ... -
Computational workflow for investigating highly variable genes in single-cell RNA-seq across multiple time points and cell types.
(2023-09-15)Here, we present a computational approach for investigating highly variable genes (HVGs) associated with biological pathways of interest, across multiple time points and cell types in single-cell RNA-sequencing (scRNA-seq) ... -
Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts.
(2022-04-01)Spinal muscular atrophy (SMA) is a severe, debilitating neuromuscular condition characterised by loss of motor neurons and progressive muscle wasting. SMA is caused by a loss of expression of SMN1 that encodes the survival ... -
Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence.
(2022-04-15)Effective clinical management of acute dengue virus (DENV) infection relies on the timing of suitable treatments during the disease progression. We analyzed single-cell transcriptomic profiles of the peripheral blood ...