Browsing Centre for Immunobiology by Subject "Interleukin-2"

Now showing items 1-3 of 3

    • Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis. 

      Scheel-Toellner, D; Raza, K; Assi, L; Pilling, D; Ross, EJ; Lee, WY; Curnow, SJ; Buckley, CD; Akbar, AN; Lord, JM (2008-01)
      Activated T cells require anti-apoptotic cytokines for their survival. The anti-apoptotic effects of these factors are mediated by their influence on the balance of expression and localisation of pro- and anti-apoptotic ...

    • Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. 

      Bénéchet, AP; De Simone, G; Di Lucia, P; Cilenti, F; Barbiera, G; Le Bert, N; Fumagalli, V; Lusito, E; Moalli, F; Bianchessi, V (2019-10)
      The responses of CD8+ T cells to hepatotropic viruses such as hepatitis B range from dysfunction to differentiation into effector cells, but the mechanisms that underlie these distinct outcomes remain poorly understood. ...

    • Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: the STALWART study. 

      Tavel, JA; INSIGHT STALWART Study Group; Babiker, A; Fox, L; Gey, D; Lopardo, G; Markowitz, N; Paton, N; Wentworth, D; Wyman, N (2010-02-23)
      BACKGROUND: The Study of Aldesleukin with and without antiretroviral therapy (STALWART) evaluated whether intermittent interleukin-2 (IL-2) alone or with antiretroviral therapy (ART) around IL-2 cycles increased CD4(+) ...