Browsing Centre for Immunobiology by Subject "Gene Expression Regulation"
Now showing items 1-4 of 4
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Epigenetic control of retrotransposons in adult tissues: implications for immune regulation.
(2017-08)Retrotransposons tune immune reactivity in differentiated cells because when they are transcribed, their nucleic acids can be viewed as non-self leading to innate immune sensing. Most retrotransposons, however, are subject ... -
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.
(2018-10)Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through ... -
Retrotransposons shape species-specific embryonic stem cell gene expression.
(2015-05-29)Over half of our genome is composed of retrotransposons, which are mobile elements that can readily amplify their copy number by replicating through an RNA intermediate. Most of these elements are no longer mobile but still ... -
Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues.
(2016-03-21)KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result ...