Browsing Centre for Immunobiology by Author "O'Leary, DD"
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Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling
Vinaiphat, A; Pazhanchamy, K; JebaMercy, G; Ngan, SC; Leow, MK-S; Ho, HH; Gao, Y-G; Lim, KL; Richards, AM; de Kleijn, DPV (American Heart Association, 2023-01-26)Background: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. Despite extensive epidemiological ... -
Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation
Kalailingam, P; Mohd-Kahliab, K-H; Ngan, SC; Iyappan, R; Melekh, E; Lu, T; Zien, GW; Sharma, B; Guo, T; MacNeil, AJ (Wiley, 2023-11-16)Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age-linked damage to amino acid sequence NGR (Asn-Gly-Arg) results in "gain-of-function" ...