Browsing Centre for Immunobiology by Author "Gadhok, R"
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Epigenetic and metabolic reprogramming of fibroblasts in Crohn's disease strictures reveals histone deacetylases as therapeutic targets.
Lewis, A; Humphreys, DT; Pan-Castillo, B; Berti, G; Felice, C; Gordon, H; Gadhok, R; Nijhuis, A; Mehta S, S; Eleid, L (2023-12-09)BACKGROUND & AIMS: No effective therapeutic intervention exists for intestinal fibrosis in Crohn's disease [CD]. We characterised fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis ...