A genotype-specific baseline score predicts post-treatment response to peginterferon alfa-2a in hepatitis B e antigen-negative chronic hepatitis B.
dc.contributor.author | Lampertico, P | |
dc.contributor.author | Messinger, D | |
dc.contributor.author | Cornberg, M | |
dc.contributor.author | Brunetto, M | |
dc.contributor.author | Petersen, J | |
dc.contributor.author | Kennedy, P | |
dc.contributor.author | Asselah, T | |
dc.contributor.author | Rothe, V | |
dc.contributor.author | Caputo, A | |
dc.contributor.author | Bakalos, G | |
dc.contributor.author | Pavlovic, V | |
dc.contributor.author | Papatheodoridis, GV | |
dc.date.accessioned | 2019-02-25T10:08:06Z | |
dc.date.available | 2018-06-14 | |
dc.date.available | 2019-02-25T10:08:06Z | |
dc.date.issued | 2018-07-26 | |
dc.identifier.issn | 1108-7471 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/55524 | |
dc.description.abstract | Background: Peginterferon alfa-2a induces durable responses in some hepatitis B e antigen-negative patients, but robust pretreatment predictors are not available to identify likely responders. In this study we aimed to develop genotype-specific baseline scoring systems to predict response. Methods: Data from 323 hepatitis B e antigen-negative peginterferon alfa-2a recipients from three studies were analyzed. Scoring systems were developed using generalized additive models and multiple logistic regression analysis. Response was defined as hepatitis B virus DNA <2000 IU/mL alone (virological response) or in combination with alanine aminotransferase normalization (combined response) 48 weeks post-treatment. Results: Points were assigned to genotype B/C patients for: age, alanine aminotransferase ratio, genotype B or C, and hepatitis B surface antigen level; and to genotype D patients for age, hepatitis B surface antigen level and hepatitis B virus DNA level. Higher total scores (range 0-5 for B/C; 0-3 for D) indicated a higher likelihood of response. Among genotype B/C patients with scores of 0-1, 2 and ≥3, respectively, virological response rates were 16.7%, 25.8% and 70.2%, and combined response rates were 12.5%, 21.0% and 57.4%. Among genotype D patients with scores of 0-1, 2 and 3, respectively, virological response rates were 10.1%, 28.0% and 50.0%, and combined response rates were 7.8%, 28.0% and 33.3%. Conclusion: Genotype-specific baseline scoring systems can identify hepatitis B e antigen-negative patients with low or high likelihood of achieving sustained responses to peginterferon alfa-2a. | en_US |
dc.description.sponsorship | F. Hoffmann-La Roche | en_US |
dc.format.extent | 712 - 721 | |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Hellenic Society of Gastroenterology | en_US |
dc.relation.ispartof | Ann Gastroenterol | |
dc.subject | HBeAg | en_US |
dc.subject | HBsAg | en_US |
dc.subject | Predictors | en_US |
dc.subject | treatment | en_US |
dc.subject | virological response | en_US |
dc.title | A genotype-specific baseline score predicts post-treatment response to peginterferon alfa-2a in hepatitis B e antigen-negative chronic hepatitis B. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2018 Hellenic Society of Gastroenterology | |
dc.identifier.doi | 10.20524/aog.2018.0300 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30386122 | en_US |
pubs.issue | 6 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 31 | en_US |
dcterms.dateAccepted | 2018-06-14 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
Files in this item
This item appears in the following Collection(s)
-
Centre for Immunobiology [1155]