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    Pseudoacromegaly

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    Accepted version (2.461Mb)
    Publisher
    Elsevier/Science Direct
    DOI
    10.1016/j.yfrne.2018.11.001
    Journal
    Frontiers in Neuroendocrinology
    ISSN
    0091-3022
    Metadata
    Show full item record
    Abstract
    © 2018 Elsevier Inc. Individuals with acromegaloid physical appearance or tall stature may be referred to endocrinologists to exclude growth hormone (GH) excess. While some of these subjects could be healthy individuals with normal variants of growth or physical traits, others will have acromegaly or pituitary gigantism, which are, in general, straightforward diagnoses upon assessment of the GH/IGF-1 axis. However, some patients with physical features resembling acromegaly – usually affecting the face and extremities –, or gigantism – accelerated growth/tall stature – will have no abnormalities in the GH axis. This scenario is termed pseudoacromegaly, and its correct diagnosis can be challenging due to the rarity and variability of these conditions, as well as due to significant overlap in their characteristics. In this review we aim to provide a comprehensive overview of pseudoacromegaly conditions, highlighting their similarities and differences with acromegaly and pituitary gigantism, to aid physicians with the diagnosis of patients with pseudoacromegaly.
    Authors
    Marques, P; Korbonits, M
    URI
    https://qmro.qmul.ac.uk/xmlui/handle/123456789/55057
    Collections
    • Centre for Endocrinology [341]
    Licence information
    CC-BY-NC-BY-ND
    Copyright statements
    2018 Elsevier Inc
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