• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Feedback control architecture and the bacterial chemotaxis network. 
    •   QMRO Home
    • Institute of Health Sciences Education
    • Centre for Medical Education
    • Feedback control architecture and the bacterial chemotaxis network.
    •   QMRO Home
    • Institute of Health Sciences Education
    • Centre for Medical Education
    • Feedback control architecture and the bacterial chemotaxis network.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Feedback control architecture and the bacterial chemotaxis network.

    View/Open
    ROBERTSFeedbackControl2011FINAL.pdf (1.483Mb)
    Volume
    7
    Pagination
    e1001130 - ?
    DOI
    10.1371/journal.pcbi.1001130
    Journal
    PLoS Comput Biol
    Issue
    5
    Metadata
    Show full item record
    Abstract
    Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance.
    Authors
    Hamadeh, A; Roberts, MAJ; August, E; McSharry, PE; Maini, PK; Armitage, JP; Papachristodoulou, A
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/5435
    Collections
    • Centre for Medical Education [80]
    Language
    eng
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.