Fostamatinib for persistent/chronic adult immune thrombocytopenia.
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Published version
Embargoed until: 5555-01-01
Embargoed until: 5555-01-01
Volume
10
Pagination
9 - 25
DOI
10.2217/imt-2017-0097
Journal
Immunotherapy
Issue
Metadata
Show full item recordAbstract
Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by phagocytosis and destruction of autoantibody-coated platelets via spleen tyrosine kinase (Syk)-mediated signal transduction in macrophages. Effectiveness of existing therapies varies, and even leading treatments (e.g., IVIg, splenectomy, rituximab, thrombopoietic agents) do not provide optimal management for a substantial number of patients with chronic ITP. Fostamatinib disodium is an orally-bioavailable investigational agent being developed for treatment of primary persistent/chronic adult ITP. Fostamatinib inhibits FcR-triggered, Syk-dependent cytoskeletal rearrangement during phagocytosis. Promising findings have been described in several autoimmune diseases, including rheumatoid arthritis, and sustained responses with manageable adverse events observed with ongoing treatment in patients with heavily treated chronic ITP. Fostamatinib represents an active therapy targeting a previously unexplored mechanism of ITP pathogenesis.
Authors
Newland, A; Lee, E-J; McDonald, V; Bussel, JBCollections
- Centre for Immunobiology [1122]