dc.contributor.author | Chan, MV | en_US |
dc.contributor.author | Leadbeater, PD | en_US |
dc.contributor.author | Watson, SP | en_US |
dc.contributor.author | Warner, TD | en_US |
dc.date.accessioned | 2018-06-08T12:33:07Z | |
dc.date.available | 2018-04-09 | en_US |
dc.date.issued | 2018-11 | en_US |
dc.date.submitted | 2018-05-10T10:13:46.563Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/39405 | |
dc.description.abstract | In this short article, submitted as part of the review on platelet function testing, we illustrate the quantitative and qualitative differences between classical light transmission aggregometry (LTA) and 96-well plate aggregometry. We show that responses to platelet agonists and antagonists differ depending upon the method of aggregation testing. For example, in 96-well aggregometry, responses to collagen are strongly inhibited by P2Y12 receptor antagonists while in LTA they are much less affected. Furthermore, we explore the importance of differences in the mechanical environment upon platelet aggregation. We emphasize that LTA and 96-well aggregometry are not interchangeable assays. These two assays are best used as complementary tests to explore platelet function in depth. | en_US |
dc.format.extent | 686 - 689 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Platelets | en_US |
dc.rights | “This is the Author’s Original Manuscript of an article published by Taylor & Francis in Platelets on 01 May 2018 available online: https://doi.org/10.1080/09537104.2018.1466388 " | |
dc.subject | 96-well | en_US |
dc.subject | light transmission | en_US |
dc.subject | platelet reactivity | en_US |
dc.subject | Adenosine Diphosphate | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Humans | en_US |
dc.subject | Platelet Activation | en_US |
dc.subject | Platelet Aggregation | en_US |
dc.subject | Platelet Function Tests | en_US |
dc.title | Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1080/09537104.2018.1466388 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29715047 | en_US |
pubs.issue | 7 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 29 | en_US |
qmul.funder | Platelet response phenotyping to improve anti-thrombotic therapy::British Heart Foundation | en_US |