dc.contributor.author | Macdougall, CE | en_US |
dc.contributor.author | Wood, EG | en_US |
dc.contributor.author | Loschko, J | en_US |
dc.contributor.author | Scagliotti, V | en_US |
dc.contributor.author | Cassidy, FC | en_US |
dc.contributor.author | Robinson, ME | en_US |
dc.contributor.author | Feldhahn, N | en_US |
dc.contributor.author | Castellano, L | en_US |
dc.contributor.author | Voisin, M-B | en_US |
dc.contributor.author | Marelli-Berg, F | en_US |
dc.contributor.author | Gaston-Massuet, C | en_US |
dc.contributor.author | Charalambous, M | en_US |
dc.contributor.author | Longhi, MP | en_US |
dc.date.accessioned | 2018-04-30T10:03:42Z | |
dc.date.available | 2018-02-02 | en_US |
dc.date.issued | 2018-03-06 | en_US |
dc.date.submitted | 2018-03-07T12:43:54.151Z | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/36587 | |
dc.description.abstract | Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation. | en_US |
dc.description.sponsorship | British Heart Foundation | en_US |
dc.format.extent | 588 - 601.e4 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Cell Metab | en_US |
dc.rights | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |
dc.subject | Pparγ | en_US |
dc.subject | adipose tissue | en_US |
dc.subject | dendritic cells | en_US |
dc.subject | diabetes | en_US |
dc.subject | homeostasis | en_US |
dc.subject | inflammation | en_US |
dc.subject | insulin resistance | en_US |
dc.subject | β-catenin | en_US |
dc.title | Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. | en_US |
dc.type | Article | |
dc.rights.holder | (c) 2018 The Author(s). | |
dc.identifier.doi | 10.1016/j.cmet.2018.02.007 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29514067 | en_US |
pubs.issue | 3 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 27 | en_US |
dcterms.dateAccepted | 2018-02-02 | en_US |
qmul.funder | Neutrophil Migration through lymphatic vessels and their role in acquired immunity in rheumatoid arthritis::Arthritis Research UK | en_US |
qmul.funder | Neutrophil Migration through lymphatic vessels and their role in acquired immunity in rheumatoid arthritis::Arthritis Research UK | en_US |